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Safety & Infection ControlScreen 36-37 wks gestation

Group B StreptococcusNCLEX cheat sheet

Group B Streptococcus is a bacterium that can colonize the vagina and rectum without harming the mother but may cause life-threatening sepsis, pneumonia, or meningitis in the newborn if transmitted during birth.

17 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Def

  • Maternal vaginal/rectal flora
  • Risk neonatal sepsis, pneumonia

Do

  • Vaginal-rectal swab 36-37 wks
  • IV penicillin in labor if +
  • First dose ≥ 4 hr before birth

Meds

  • Pen G first-line, ampicillin alt
  • PCN allergy → clindamycin/vanco

Report

  • Newborn: temp instability, grunting
  • Poor feeding, lethargy in baby
Key takeaway

All pregnant clients are screened with a vaginal-rectal culture at 36 to 37 weeks gestation.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A pregnant nurse is assigned a group of pediatric patients. Which child should she avoid caring for to protect her fetus?

What is group b streptococcus?

Universal screening and intrapartum antibiotics dramatically reduce neonatal infection. Prevention centers on timely penicillin during labor.

Key points to remember

  • All pregnant clients are screened with a vaginal-rectal culture at 36 to 37 weeks gestation.
  • GBS-positive clients receive IV antibiotic prophylaxis during labor, ideally at least 4 hours before delivery.
  • Intravenous penicillin G is the first-line agent; ampicillin is an alternative, and cefazolin or clindamycin/vancomycin are used for penicillin allergy.
  • Treatment is given during labor, not during pregnancy, because colonization can recur.
  • Risk factors warranting treatment without a culture include preterm labor, ruptured membranes over 18 hours, maternal fever, or a previous GBS-affected infant.

Nursing priorities

  1. Identify GBS status on admission and initiate IV antibiotics promptly once labor begins or membranes rupture.
  2. Time antibiotic administration to achieve at least 4 hours of coverage before delivery when possible.
  3. Monitor the newborn for signs of early-onset sepsis after birth.
  4. Document the number of antibiotic doses and the timing relative to delivery for the newborn team.

Labs & values

GBS vaginal-rectal culture: collected at36 to 37 weeks; positive result indicates intrapartum prophylaxis is needed
Newborn CBC and blood cultures if sepsis is suspected

Patient teaching

  • A positive GBS test does not mean you are sick; antibiotics during labor protect your baby.
  • Go to the hospital promptly when your water breaks or labor starts so antibiotics can be started in time.
  • GBS status can change, so screening is repeated with each pregnancy.

Red flags: report now

  • Newborn temperature instability, grunting, poor feeding, or lethargy may indicate GBS sepsis and require immediate evaluation.
  • Delaying or omitting intrapartum antibiotics in a GBS-positive client increases the risk of neonatal sepsis.
  • Maternal fever in labor with GBS colonization signals possible chorioamnionitis and must be reported.

References

Clinical references for this topic

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