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Safety & Infection ControlMax barrier + chlorhexidine prep

Central Line BundleNCLEX cheat sheet

The central line bundle is a set of evidence-based practices that, used together, dramatically reduce central line-associated bloodstream infections (CLABSI).

18 key facts 5 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Insert

  • Hand hygiene + max sterile barrier
  • Chlorhexidine skin prep, dry 30s
  • Avoid femoral site (infection)

Maintain

  • Scrub the hub 15s before access
  • Daily review for line removal
  • Change dressing q7d / when soiled

Report

  • Redness, drainage, fever → CLABSI
  • Air embolism: clamp, left-side, O2

Avoid

  • Never leave caps/lumens open
Red flag to remember

Never skip maximal sterile barrier precautions for a central line insertion.

Before you read

Test yourself first: 5 questions

Question 1 of 5

An infusion pump suddenly stops and displays 'air in line.' The nurse should:

What is central line bundle?

It spans insertion and maintenance. Core elements: hand hygiene, maximal sterile barriers at insertion, chlorhexidine skin antisepsis, optimal site selection, and daily review of line necessity.

Key points to remember

  • The five core elements are hand hygiene, maximal barrier precautions, chlorhexidine skin prep, optimal site selection, and daily necessity review.
  • Maximal sterile barriers at insertion include cap, mask, sterile gown, sterile gloves, and a full-body sterile drape.
  • Chlorhexidine is the preferred skin antiseptic and must dry fully before insertion.
  • The subclavian site generally carries lower infection risk than femoral; femoral is avoided when possible.
  • Scrub the hub and needleless connectors before each access (scrub the hub).
  • Removing the line as soon as it is no longer needed is a key infection-prevention step.

Nursing priorities

  1. Perform hand hygiene and ensure full maximal sterile barriers during insertion.
  2. Prep the skin with chlorhexidine and allow it to dry completely before insertion.
  3. Scrub the hub or connector with antiseptic before every access.
  4. Assess line necessity daily and advocate removal when no longer needed.
  5. Maintain a sterile occlusive dressing and change it per protocol or when soiled or loose.

Labs & values

Blood cultures (peripheral and from the line) to diagnose CLABSI
WBC: normal5,000-10,000 cells/mm3; elevation may indicate infection

Patient teaching

  • Keep the dressing clean, dry, and intact and report if it loosens or gets wet.
  • Report fever, chills, or redness and tenderness at the insertion site.

Red flags: report now

  • Never skip maximal sterile barrier precautions for a central line insertion.
  • Do not leave a central line in place once it is no longer clinically needed.
  • Report redness, drainage, or fever, which may signal a bloodstream infection.

References

Clinical references for this topic

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