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Safety & Infection ControlThe most effective way to prevent infection

Hand HygieneNCLEX cheat sheet

Hand hygiene is the single most effective action to prevent healthcare-associated infections.

16 key facts 5 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

When

  • Before/after every patient contact
  • After glove removal, before invasive
  • After body fluids, restroom

Do

  • Soap + water ≥ 20 sec scrub
  • Alcohol gel ok if not visibly soiled
  • Dry hands lower than elbows

Soap Only

  • C. diff + spores → soap & water
  • Visibly soiled → no alcohol gel

Avoid

  • No artificial nails (clinical staff)
Red flag to remember

Never rely on alcohol-based rub alone for C. difficile or norovirus; spores require soap and water.

Before you read

Test yourself first: 5 questions

Question 1 of 5

The nurse observes a colleague who removed gloves but is about to leave an isolation room without performing hand hygiene. What is the nurse's best action?

What is hand hygiene?

It includes alcohol-based hand rub for routine decontamination and soap-and-water handwashing when hands are visibly soiled or after spore-forming organisms. The CDC five moments frame when to clean hands around patient care.

Hand Hygiene illustrated

Hand Hygiene — medical illustration
Hand Hygiene — medical illustration. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Hand hygiene is the most important single measure to reduce healthcare-associated infections.
  • Wash with soap and water when hands are visibly soiled, after using the restroom, and for C. difficile or norovirus.
  • Alcohol-based rub is acceptable and often preferred for routine hand decontamination when hands are not visibly dirty.
  • Soap-and-water handwashing requires at least 15 to 20 seconds of friction.
  • Clean hands before and after patient contact, before aseptic tasks, after body-fluid exposure, and after touching surroundings.
  • Hand hygiene is performed before donning and after removing gloves.

Nursing priorities

  1. Use soap and water when hands are visibly soiled or after caring for C. difficile or norovirus patients.
  2. Apply alcohol-based rub until hands are dry for routine decontamination.
  3. Scrub for at least 15 to 20 seconds covering all surfaces, including between fingers and under nails.
  4. Perform hand hygiene immediately after glove removal.

Patient teaching

  • Teach families to wash hands before and after visiting and before eating.
  • Keep fingernails short and avoid artificial nails, which harbor organisms.
  • Rub alcohol gel over all surfaces until completely dry; do not wipe it off.

Red flags: report now

  • Never rely on alcohol-based rub alone for C. difficile or norovirus; spores require soap and water.
  • Do not treat gloves as a replacement for hand hygiene.
  • Report inability to perform hand hygiene (e.g., no supplies) so it can be corrected.

References

Clinical references for this topic

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