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Safety & Infection ControlContact precautions, gown + gloves

MRSANCLEX cheat sheet

MRSA is Staphylococcus aureus that has become resistant to methicillin and most beta-lactam antibiotics, making infections harder to treat.

21 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Define

  • Methicillin-resistant S. aureus
  • Colonizes nares, skin, wounds

Precautions

  • Contact: gown + gloves, private room
  • Dedicated equipment in room

Meds

  • Vancomycin = drug of choice
  • Monitor trough, watch nephrotoxicity

Teach

  • Hand hygiene = #1 prevention
  • Decolonize: mupirocin nares, CHG bath
Red flag to remember

Spreading erythema, fever, hypotension, or tachycardia may indicate bacteremia or sepsis and must be reported immediately.

Before you read

Test yourself first: 3 questions

Question 1 of 3

Which of the following clients should the charge nurse assign to a private negative-pressure airborne isolation room?

What is mrsa?

It commonly causes skin and soft-tissue infections (abscesses, cellulitis) but can also cause pneumonia, bacteremia, and surgical-site infections. People may be colonized (carrying it without illness, often in the nares) or actively infected. Contact precautions and prudent antibiotic use limit its spread.

Key points to remember

  • MRSA frequently appears as a red, swollen, painful, often purulent skin lesion that may look like a spider bite or boil.
  • It is spread mainly by direct contact and contaminated hands, surfaces, and shared items.
  • Colonization (especially nasal) means carriage without symptoms; infection means active disease.
  • Vancomycin and linezolid are common treatment choices because the organism resists penicillins and cephalosporins.
  • Healthcare-associated MRSA often causes bloodstream, wound, and ventilator-associated pneumonia infections.
  • Contact precautions with gown and gloves are required to prevent transmission.

Nursing priorities

  1. Place the patient on contact precautions with gown and gloves and a private room or cohort.
  2. Perform meticulous hand hygiene and dedicate equipment to the patient.
  3. Administer vancomycin or other ordered antibiotics and monitor for therapeutic levels and adverse effects.
  4. Care for wounds with sterile technique and keep drainage contained and covered.
  5. Implement decolonization protocols (such as mupirocin nasal ointment and chlorhexidine baths) when ordered.

Labs & values

Vancomycin trough goal typically15-20 mcg/mL for serious infection
WBC normal5,000-10,000/mm3 (elevated with active infection)
Wound or blood culture positive for MRSA
1520mcg/mL Normal

Patient teaching

  • Keep wounds clean, dry, and covered, and do not share towels, razors, or personal items.
  • Wash hands frequently and complete the entire antibiotic course even if you feel better.
  • Report increasing redness, warmth, drainage, or fever around a wound to the provider.

Red flags: report now

  • Spreading erythema, fever, hypotension, or tachycardia may indicate bacteremia or sepsis and must be reported immediately.
  • Monitor vancomycin trough levels and renal function; report signs of nephrotoxicity or red man syndrome with rapid infusion.
  • Never allow MRSA wound drainage to contact other patients or shared equipment.
  • New respiratory distress in a MRSA-positive patient may signal MRSA pneumonia needing urgent attention.

References

Clinical references for this topic

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