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Needlestick ExposureNCLEX cheat sheet

A needlestick or sharps exposure risks transmission of bloodborne pathogens, chiefly hepatitis B, hepatitis C, and HIV.

17 key facts 5 practice questions Reviewed Oct 2026
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Do First

  • Wash site w/ soap + water now
  • Flush mucous membranes w/ water
  • Report to supervisor immediately

Next

  • Source + employee blood: HIV/HBV/HCV
  • HIV PEP within hours (best < 2h)

Avoid

  • Don't squeeze/milk the wound
  • Never recap needle (cause)

Prevent

  • Use safety-engineered devices
  • Sharps box at point of use
Red flag to remember

Never recap, bend, or break needles; recapping is a leading cause of sharps injuries.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A nurse experiences a needlestick injury from a needle used on a client with HIV. What is the nurse's FIRST action?

What is needlestick exposure?

Immediate first aid plus rapid reporting drives effective post-exposure prophylaxis. The first action after the injury is to wash the site, not to report; time matters most for HIV prophylaxis.

Key points to remember

  • Bloodborne pathogens of greatest concern are hepatitis B, hepatitis C, and HIV.
  • The first action is to wash the site with soap and water; mucous membranes are flushed with water or saline.
  • Do not squeeze the wound to bleed it; this can worsen tissue trauma without reducing risk.
  • HIV post-exposure prophylaxis is most effective when started within hours, ideally within 1 to 2 hours.
  • Most needlesticks are preventable by never recapping needles and using safety-engineered devices.
  • Both the source patient and the exposed worker are tested per protocol after consent.

Nursing priorities

  1. Immediately wash the wound with soap and water and flush mucous membranes with water or saline.
  2. Report the exposure to the supervisor and occupational/employee health without delay.
  3. Initiate baseline and source-patient bloodborne pathogen testing per facility protocol.
  4. Start prescribed HIV post-exposure prophylaxis as soon as possible after exposure.

Labs & values

Baseline and follow-up: HIV antibody/antigen, hepatitis B surface antigen and antibody, hepatitis C antibody
Hepatitis B surface antibody (anti-HBs)10 mIU/mL or higher indicates protective immunity

Patient teaching

  • Report every needlestick even if it seems minor; do not self-manage exposures.
  • Stay up to date on the hepatitis B vaccine series for protection.

Red flags: report now

  • Never recap, bend, or break needles; recapping is a leading cause of sharps injuries.
  • Do not delay reporting; HIV prophylaxis effectiveness drops sharply with time.
  • Report any failure of a sharps safety device so it can be removed from use.

References

Clinical references for this topic

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