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Poisoning General ManagementNCLEX cheat sheet

Poisoning results from ingestion, inhalation, injection, or absorption of a toxic substance and can rapidly impair the airway, breathing, and circulation.

23 key facts 4 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Do

  • ABCs first, then identify agent
  • Activated charcoal if appropriate
  • Bring container/pill bottle

Antidotes

  • Acetaminophen → N-acetylcysteine
  • Opioid → naloxone
  • Benzo → flumazenil

Avoid

  • NO charcoal if caustic/acid
  • Don't induce vomiting

Watch

  • Caustic → dilute water/milk
  • Protect airway if ↓LOC
Key takeaway

Supportive care of airway, breathing, and circulation takes priority over identifying the exact substance.

Before you read

Test yourself first: 4 questions

Question 1 of 4

Which is true about disclosing a medication error to the client?

What is poisoning general management?

Management centers on supporting the ABCs, identifying the toxin, and limiting absorption. Always contact Poison Control for guidance on specific agents and antidotes.

Key points to remember

  • Supportive care of airway, breathing, and circulation takes priority over identifying the exact substance.
  • Activated charcoal can adsorb many ingested toxins if given early, but is contraindicated for caustics, hydrocarbons, and decreased level of consciousness due to aspiration risk.
  • Syrup of ipecac and induced vomiting are no longer recommended.
  • Specific antidotes include naloxone for opioids, N-acetylcysteine for acetaminophen, flumazenil for benzodiazepines, and atropine for organophosphates.
  • Caustic ingestions (acids/alkalis) should not be neutralized or induced to vomit due to re-injury risk.
  • Carbon monoxide poisoning causes falsely normal pulse oximetry and is treated with 100% oxygen.

Nursing priorities

  1. Assess and support airway, breathing, and circulation first.
  2. Call Poison Control and identify the substance, amount, and time of exposure.
  3. Administer the appropriate antidote and decontaminate (skin/eye irrigation, activated charcoal when indicated).
  4. Establish IV access and monitor cardiac rhythm, mental status, and vital signs.
  5. Send labs and toxicology screens and protect the airway in the obtunded patient.

Labs & values

Acetaminophen level (toxic via nomogram)
Carboxyhemoglobin elevated in CO poisoning (normal <3%)
ABG and anion gap for toxic alcohols
Glucose, electrolytes, and creatinine/BUN

Patient teaching

  • Keep the Poison Control number (1-800-222-1222) posted and call before treating.
  • Store medications and chemicals in original, locked, child-proof containers away from children.
  • Do not induce vomiting unless specifically directed by Poison Control.
  • Install carbon monoxide detectors in the home.

Red flags: report now

  • Decreasing level of consciousness threatens the airway - do not give oral charcoal to an unprotected airway.
  • Never induce vomiting after caustic or hydrocarbon ingestion.
  • Normal pulse ox does not rule out carbon monoxide poisoning - treat with 100% oxygen.
  • Report new dysrhythmias, seizures, or rapidly worsening mental status immediately.

References

Clinical references for this topic

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