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Vaccination for AdultsNCLEX cheat sheet

Adult immunizations prevent serious infectious disease and are a key primary prevention strategy.

16 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Routine

  • Influenza: yearly all adults
  • Td/Tdap booster q10y
  • COVID per current guidance

Older 50-65+

  • Shingles (RZV) 50+, 2 doses
  • Pneumococcal 65+ (or risk)
  • RSV 60-75+ shared decision

Avoid

  • Live vaccine → no if pregnant
  • Live → no if immunocompromised
  • Hold if egg/component anaphylaxis

Teach

  • Soreness/low fever = normal
  • Hep B if diabetic/HCW/risk
Red flag to remember

Never give live vaccines to pregnant or significantly immunocompromised patients.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A pregnant client is found to be nonimmune to rubella on prenatal screening. Which instruction should the nurse provide regarding the rubella vaccine?

What is vaccination for adults?

Recommendations vary by age, health conditions, and risk. Live vaccines are contraindicated in pregnancy and immunocompromised patients.

Key points to remember

  • Influenza vaccine is recommended annually for all adults.
  • Td or Tdap booster is given every 10 years; Tdap is given each pregnancy.
  • Shingles (recombinant zoster) vaccine is recommended at age 50 and older, given as two doses.
  • Pneumococcal vaccine is recommended at age 65 and older, and earlier with chronic conditions.
  • Live vaccines (MMR, varicella, intranasal flu) are contraindicated in pregnancy and immunocompromise.
  • COVID-19 and RSV vaccines are recommended for older and high-risk adults.

Nursing priorities

  1. Review immunization history and identify due or overdue vaccines at each visit.
  2. Screen for contraindications such as pregnancy, immunosuppression, and severe egg or component allergy.
  3. Administer vaccines correctly and document site, route, lot number, and education provided.
  4. Observe for an immediate allergic reaction after administration and have epinephrine available.
  5. Educate patients on expected mild side effects versus reactions to report.

Patient teaching

  • Mild soreness, low-grade fever, and fatigue are common and resolve in a day or two.
  • Get the flu vaccine every year and a Td/Tdap booster every 10 years; report any difficulty breathing or swelling.

Red flags: report now

  • Never give live vaccines to pregnant or significantly immunocompromised patients.
  • Signs of anaphylaxis (wheezing, swelling, hypotension) after a vaccine require epinephrine and rapid response now.
  • A history of anaphylaxis to a prior dose or vaccine component is a contraindication and is verified before giving.

References

Clinical references for this topic

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