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Pharmacological TherapiesNeutralize acid → fast, short relief

AntacidsNCLEX cheat sheet

Antacids neutralize existing stomach acid to provide rapid, short-lived relief of heartburn, indigestion, and reflux.

21 key facts 3 practice questions Reviewed Oct 2026
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Types

  • Mg → diarrhea; Al → constipation
  • Ca carbonate → gas, rebound acid

Do

  • Take 1-3 hr after meals & HS
  • Separate other meds by 1-2 hr

Avoid

  • Renal failure → Mg toxicity risk
  • ↓ absorption of many drugs

Report

  • Pain > 2 wk, black/bloody stool
Red flag to remember

Report worsening or persistent heartburn beyond 2 weeks of self-treatment.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A home care nurse is teaching a client about a new prescription for oral iron supplements for iron-deficiency anemia. Which instruction enhances iron absorption?

What is antacids?

Common types include calcium carbonate, magnesium hydroxide, aluminum hydroxide, and sodium bicarbonate. Memory aid: magnesium causes diarrhea ('Mg = Must Go') and aluminum/calcium cause constipation, so they are often combined.

Key points to remember

  • Provide fast but brief relief by neutralizing acid already present in the stomach.
  • Magnesium-based products cause diarrhea, while aluminum- and calcium-based products cause constipation.
  • Calcium carbonate can cause rebound acid hypersecretion and, in excess, milk-alkali syndrome with hypercalcemia.
  • Magnesium antacids are dangerous in renal impairment due to magnesium accumulation.
  • Antacids reduce absorption of many drugs (tetracyclines, fluoroquinolones, levothyroxine, iron, digoxin).
  • Sodium bicarbonate adds a high sodium load, a concern in heart failure and hypertension.

Nursing priorities

  1. Separate antacids from other oral medications by 1 to 2 hours.
  2. Assess kidney function before giving magnesium-containing antacids.
  3. Monitor bowel pattern and adjust the type if diarrhea or constipation develops.
  4. Monitor calcium and magnesium levels with frequent use.
  5. Assess sodium content for patients with heart failure or hypertension.

Labs & values

Calcium9.0-10.5 mg/dL
Magnesium1.3-2.1 mg/dL
Sodium135-145 mEq/L
9.010.5mg/dL Normal

Patient teaching

  • Take other medicines 1 to 2 hours apart from antacids.
  • Choose magnesium products if constipated and aluminum/calcium if loose stools occur.
  • Limit sodium bicarbonate if you have heart failure or high blood pressure.
  • See your provider if heartburn lasts more than 2 weeks.

Red flags: report now

  • Report worsening or persistent heartburn beyond 2 weeks of self-treatment.
  • Report confusion, weakness, or palpitations from electrolyte disturbance (hypermagnesemia/hypercalcemia).
  • Never give magnesium-based antacids to patients with renal failure.

References

Clinical references for this topic

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