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Pharmacological Therapies-sone → never stop abruptly

CorticosteroidsNCLEX cheat sheet

Corticosteroids (prednisone, methylprednisolone, dexamethasone, hydrocortisone) suppress inflammation and the immune response and are used for autoimmune, inflammatory, allergic, and respiratory conditions.

24 key facts 5 practice questions Reviewed Oct 2026
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Meds

  • Prednisone, dexamethasone, hydrocortisone
  • ↓ inflammation, suppress immune

Signs

  • ↑ glucose, ↑ wt, moon face
  • ↓ K+, ↑ Na+, fluid retention
  • Mood swings, ↑ infection risk

Do

  • Take w/ food, give in AM
  • TAPER slowly off, monitor BG

Report

  • Abrupt stop → adrenal crisis
  • Masks infection signs, GI bleed
Key takeaway

They raise blood glucose (hyperglycemia), so diabetics need closer glucose monitoring.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client on long-term oral corticosteroids asks about stopping them. The nurse teaches to:

What is corticosteroids?

Chronic use causes Cushingoid effects and adrenal suppression, so the drug must never be stopped abruptly. Memory aid: steroids cause a 'moon face' and raise sugar, weight, and infection risk.

Key points to remember

  • They raise blood glucose (hyperglycemia), so diabetics need closer glucose monitoring.
  • They suppress the immune system, increasing infection risk and masking the signs of infection such as fever.
  • Long-term use causes Cushingoid features: moon face, buffalo hump, truncal obesity, thin skin, easy bruising, and striae.
  • They cause sodium and water retention with potassium loss, leading to edema, hypertension, and hypokalemia.
  • Chronic use causes osteoporosis, muscle wasting, mood changes, cataracts, and GI ulcers.
  • Abrupt withdrawal after long-term use can trigger life-threatening adrenal crisis.

Signs & symptoms

  • ↑ glucose, ↑ wt, moon face
  • ↓ K+, ↑ Na+, fluid retention
  • Mood swings, ↑ infection risk

Nursing priorities

  1. Monitor blood glucose, blood pressure, weight, and signs of infection.
  2. Administer oral doses with food to reduce GI irritation and ulcer risk.
  3. Taper the dose gradually rather than stopping abruptly.
  4. Protect the patient from infection and exposure to ill people.
  5. Monitor potassium and assess for edema and fluid retention.

Labs & values

Blood glucose (fasting70-99 mg/dL) - watch for hyperglycemia
Potassium (3.5-5.0 mEq/L) - watch for hypokalemia
WBC (5,000-10,000/mm3)
7099mg/dL Normal

Patient teaching

  • Never stop the medication suddenly; it must be tapered by your provider.
  • Avoid people who are sick and report fever or signs of infection.
  • Take the medication with food, and carry medical identification stating you take steroids.

Red flags: report now

  • Signs of infection (which may be subtle or fever may be masked) require prompt evaluation.
  • Abrupt discontinuation after prolonged use can cause adrenal crisis with hypotension, weakness, and shock.
  • Black, tarry stools or signs of GI bleeding.
  • Markedly elevated blood glucose or severe hyperglycemia.

References

Clinical references for this topic

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