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Pharmacological TherapiesNon-DHP CCB → slows AV node

DiltiazemNCLEX cheat sheet

Diltiazem is a non-dihydropyridine calcium channel blocker used for rate control in atrial fibrillation and flutter, supraventricular tachycardia, hypertension, and angina.

20 key facts 2 practice questions Reviewed Oct 2026
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Uses

  • HTN, angina, A-fib/SVT rate control
  • Blocks Ca → ↓ HR, ↓ contractility

Signs

  • Bradycardia, hypotension, edema
  • Dizziness, constipation, flushing

Report

  • HR < 60 → hold dose
  • SBP < 90, new SOB/swelling

Avoid

  • NEVER w/ IV beta-blocker → asystole
  • Heart block, HFrEF caution
  • No grapefruit juice → ↑ levels

Teach

  • Check pulse before each dose
  • Rise slowly, ↑ fiber/fluids
Red flag to remember

Hold and report heart rate below 60 beats per minute or systolic BP below 90 mmHg.

Before you read

Test yourself first: 2 questions

Question 1 of 2

A client with hypertension is prescribed diltiazem. The nurse should question the order if the client also has which condition?

What is diltiazem?

It slows AV node conduction, reduces heart rate, and relaxes vascular smooth muscle to lower blood pressure. Both IV and oral forms are used.

Key points to remember

  • Slows AV nodal conduction and heart rate, making it effective for rate control in atrial fibrillation.
  • Lowers blood pressure through arterial vasodilation and can cause bradycardia and hypotension.
  • Should not be combined with IV beta blockers because of additive risk of profound bradycardia and heart block.
  • Contraindicated in second- or third-degree heart block (without a pacemaker) and in cardiogenic shock.
  • Grapefruit juice increases drug levels by inhibiting metabolism.
  • Extended-release tablets must be swallowed whole, not crushed or chewed.

Signs & symptoms

  • Bradycardia, hypotension, edema
  • Dizziness, constipation, flushing

Nursing priorities

  1. Check apical heart rate and blood pressure before administration; hold and notify the provider if heart rate is below 60 or systolic BP is below 90 mmHg.
  2. Place the patient on continuous ECG monitoring during IV administration.
  3. Assess for signs of heart failure and peripheral edema with ongoing therapy.
  4. Teach patients to swallow extended-release forms whole and to avoid grapefruit.

Patient teaching

  • Take your pulse as instructed and report a rate below 60 or feelings of fainting.
  • Swallow extended-release tablets whole; do not crush, chew, or split them.
  • Avoid grapefruit and grapefruit juice while on this medication.
  • Rise slowly to prevent dizziness from low blood pressure.
  • Do not stop the drug abruptly, as angina or rapid heart rate can rebound.

Red flags: report now

  • Hold and report heart rate below 60 beats per minute or systolic BP below 90 mmHg.
  • Report new heart block, severe bradycardia, syncope, or worsening heart failure.
  • Never give concurrently with IV beta blockers due to the risk of cardiac standstill.

References

Clinical references for this topic

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