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IV Therapy and Site CareNCLEX cheat sheet

Peripheral IV therapy delivers fluids, medications, and blood through a catheter in a peripheral vein.

22 key facts 5 practice questions Reviewed Oct 2026
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Signs

  • Infiltration: cool, pale, swollen, no blood return
  • Phlebitis: warm, red, hard cord, tender
  • Extravasation = vesicant leak → tissue necrosis

Do

  • Stop infusion, D/C IV, elevate limb
  • Warm compress phlebitis; cool for infiltrate
  • Flush w/ saline; verify blood return

Report

  • Air embolism: sudden SOB, chest pain
  • Streaking, fever, purulent = infection

Avoid

  • Never use IV w/o blood return for vesicants
  • Don't re-prime infiltrated line
Red flag to remember

Vesicant extravasation: stop the infusion immediately, leave the catheter, aspirate, and follow antidote protocol to prevent necrosis.

Before you read

Test yourself first: 5 questions

Question 1 of 5

When giving enoxaparin subcutaneously, the nurse should:

What is iv therapy and site care?

Nursing care ensures patency, prevents complications (infiltration, phlebitis, infection), and protects the site. Key principle: assess the site every shift/before each use, and stop the infusion at the first sign of a complication.

Key points to remember

  • Infiltration = a cool, pale, swollen site (fluid leaks into tissue); phlebitis = a warm, red, tender, cordlike vein (inflammation).
  • Extravasation is infiltration of a vesicant drug and can cause tissue necrosis; stop infusion immediately and follow drug-specific protocol.
  • Always verify a blood return and flush easily before administering medication.
  • Rotate peripheral sites and change the dressing per policy; assess the site for redness, swelling, and drainage every shift.
  • Use the smallest gauge that meets the therapy and choose the most distal suitable vein first.
  • Air in the line and rapid/large air boluses risk air embolism; clear air from tubing before connecting.

Signs & symptoms

  • Infiltration: cool, pale, swollen, no blood return
  • Phlebitis: warm, red, hard cord, tender
  • Extravasation = vesicant leak → tissue necrosis

Nursing priorities

  1. Assess the IV site for patency, infiltration, phlebitis, and infection before each use and routinely.
  2. Stop the infusion and discontinue the IV at the first sign of infiltration or phlebitis, then restart in a new site.
  3. Verify the right fluid/rate and check for blood return before giving IV medications.
  4. Maintain a clean/dry dressing and label tubing and site with date.
  5. Monitor for fluid overload (lung sounds, edema, weight) especially in older adults and heart/kidney clients.

Labs & values

Serum electrolytes (Na135 to 145, K 3.5 to 5.0 mEq/L)
Monitor BUN/creatinine and intake/output for fluid status

Patient teaching

  • Report pain, burning, swelling, redness, or leaking at the IV site right away.
  • Avoid bumping or pulling on the IV and tell staff if the pump alarms.
  • Keep the arm with the IV positioned to avoid kinking the line.

Red flags: report now

  • Vesicant extravasation: stop the infusion immediately, leave the catheter, aspirate, and follow antidote protocol to prevent necrosis.
  • Signs of fluid overload (dyspnea, crackles, JVD, sudden weight gain) require slowing the rate and notifying the provider.
  • Fever, site redness with purulent drainage, or red streaking suggests infection/systemic spread; report.

References

Clinical references for this topic

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