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Pharmacological TherapiesLeukotriene blocker → PREVENTION only

MontelukastNCLEX cheat sheet

Montelukast is a leukotriene receptor antagonist that blocks inflammatory leukotrienes to prevent bronchoconstriction.

14 key facts 4 practice questions Reviewed Oct 2026
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Uses

  • Asthma maintenance, allergic rhinitis
  • Blocks leukotrienes → ↓ inflammation

Do

  • Take daily in evening
  • Exercise dose ≥ 2 hr before

Avoid

  • NOT for acute attack → no rescue
  • Keep rescue inhaler on hand

Report

  • Mood change, suicidal thoughts
  • Worsening wheeze despite use
Red flag to remember

Report new or worsening mood changes, agitation, hallucinations, or suicidal thoughts immediately.

Before you read

Test yourself first: 4 questions

Question 1 of 4

A client with asthma is prescribed montelukast. The nurse explains that this medication is used for which purpose?

What is montelukast?

It is taken daily for long-term asthma control and allergic rhinitis, NOT for an acute attack. Memory aid: '-lukast' = leukotriene blocker.

Key points to remember

  • It is a controller/prophylactic drug and does NOT relieve an acute bronchospasm or asthma attack.
  • Given orally once daily, typically in the evening, with or without food.
  • Effective for both asthma and seasonal/perennial allergic rhinitis, and prevents exercise-induced bronchospasm.
  • Has a black box warning for serious neuropsychiatric events including agitation, depression, and suicidal thinking.
  • Chewable tablets contain phenylalanine, a concern for patients with phenylketonuria (PKU).

Nursing priorities

  1. Confirm the patient understands this is daily prevention, not rescue, and continues to carry a short-acting bronchodilator.
  2. Assess and document baseline mood and behavior; monitor for new agitation, depression, or suicidal ideation.
  3. Administer in the evening for asthma to align with overnight/early-morning symptoms.
  4. Screen chewable forms for phenylalanine content in patients with PKU.

Patient teaching

  • Take it every day even when you feel well; it works by preventing symptoms over time.
  • Keep using your rescue inhaler for sudden breathing trouble.
  • Report any unusual mood, sleep, or behavior changes to your provider.

Red flags: report now

  • Report new or worsening mood changes, agitation, hallucinations, or suicidal thoughts immediately.
  • Never substitute montelukast for a rescue inhaler during an acute attack.

References

Clinical references for this topic

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