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Pharmacological TherapiesNever stop abruptly

Prednisone (corticosteroid)NCLEX cheat sheet

Prednisone is an oral glucocorticoid that suppresses inflammation and the immune response.

20 key facts 5 practice questions Reviewed Oct 2026
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Action

  • Anti-inflammatory, immunosuppressant
  • Taper to avoid adrenal crisis

Effects

  • ↑glucose, ↑weight, moon face
  • ↓immunity → mask infection
  • Osteoporosis, ↑BP, ↓K+

Teach

  • Take with food in morning
  • Report infection signs, fever

Report

  • Adrenal crisis: ↓BP, weak, ↓Na
  • GI bleed: black/tarry stool
Red flag to remember

Never stop abruptly (adrenal crisis: hypotension, weakness, shock).

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client with an acute COPD exacerbation is prescribed oral prednisone. The nurse teaches the client about this corticosteroid. Which instruction is correct?

What is prednisone (corticosteroid)?

It treats autoimmune disorders, asthma, COPD exacerbations, allergic reactions, and many inflammatory conditions. Memory aid: think Cushingoid effects. Key principle: never stop abruptly because of adrenal suppression, and it masks infection.

Key points to remember

  • Long-term use causes Cushingoid effects: moon face, buffalo hump, truncal obesity, and thin skin.
  • It raises blood glucose, raises blood pressure, and causes sodium and fluid retention with potassium loss.
  • It suppresses the immune system and masks signs of infection such as fever.
  • It must be tapered, never stopped abruptly, to avoid adrenal crisis.
  • Long-term use causes osteoporosis, hyperglycemia, peptic ulcers, and delayed wound healing.

Nursing priorities

  1. Monitor blood glucose, blood pressure, weight, and signs of infection.
  2. Administer with food to reduce GI irritation and ulcer risk.
  3. Assess for subtle infection because steroids mask fever and inflammation.
  4. Teach a slow taper and never abrupt discontinuation.
  5. Monitor potassium and assess for fluid retention and edema.

Labs & values

Glucose70-99 mg/dL fasting (steroids raise it)
Potassium3.5-5.0 mEq/L (steroids lower it)
Sodium135-145 mEq/L (retained)
WBC5,000-10,000/mm3
7099mg/dL Normal

Patient teaching

  • Take with food and do not stop suddenly; taper as directed.
  • Avoid crowds and people who are sick; report any signs of infection.
  • Carry medical identification and report mood changes, swelling, or vision changes.

Red flags: report now

  • Never stop abruptly (adrenal crisis: hypotension, weakness, shock).
  • Report signs of infection, black tarry stools, or severe abdominal pain.
  • Report hyperglycemia and unexpected weight gain or swelling.

References

Clinical references for this topic

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