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Rh Incompatibility and RhoGAM — NCLEX Cheat Sheet

Rh- mom + Rh+ baby = risk

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👤 By the CinnaRN Clinical Content Team 🕐 Updated 2026-07-11 🏷️ Pharmacological Therapies 🔖 Free to read, print, and share

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Use this quick-reference guide to spot, treat, and prevent Rh Incompatibility and RhoGAM on the NCLEX. Keep it handy during review and on exam day!

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Mechanism

Key facts

Rh- mom exposed to Rh+ fetal blood
Mom makes antibodies (sensitized)
Next Rh+ baby → hemolysis

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Rhogam

Key facts

Give at 28 wks gestation
Within 72h after Rh+ delivery
Also: amnio, miscarriage, trauma

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Teach

Teaching points

RhoGAM prevents antibody formation
Given each at-risk pregnancy

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Avoid

Key facts

Useless if already sensitized

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Quick Tip

Sensitization usually does not harm the first Rh-positive baby but endangers subsequent Rh-positive pregnancies.

📖 Related Topics

Digoxin Toxicity Heparin Therapy Warfarin Therapy Acetaminophen Poisoning in Children

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