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Pharmacological TherapiesIV nutrition via central line

Total Parenteral NutritionNCLEX cheat sheet

Total parenteral nutrition delivers complete nutrition, including dextrose, amino acids, lipids, electrolytes, and vitamins, directly into the bloodstream through a central venous catheter.

23 key facts 5 practice questions Reviewed Oct 2026
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Types

  • TPN = central line, high dextrose
  • PPN = peripheral, ≤10% dextrose
  • For gut rest, NPO >7 days

Do

  • Check blood glucose q4-6h
  • Sterile dressing, daily weights
  • Change tubing/bag q24h

Avoid

  • Never stop abruptly → hypoglycemia
  • No add meds to TPN line
  • If late → run D10 not catch-up

Report

  • Fever, chills → catheter sepsis
  • Glucose >200 → cover w/ insulin
  • Air embolism: clamp, left side down
Red flag to remember

Fever, chills, or redness at the insertion site may indicate catheter-related bloodstream infection and must be reported.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client is prescribed parenteral iron dextran by the intramuscular route. Which technique should the nurse use to prevent skin staining?

What is total parenteral nutrition?

It is used when the gastrointestinal tract cannot be used, such as in bowel obstruction, severe malabsorption, or prolonged NPO status. Because it is highly concentrated and bypasses the gut, it carries significant infection and metabolic risks.

Key points to remember

  • TPN is hypertonic and high in dextrose, so it must run through a central line, not a peripheral IV.
  • Strict aseptic technique is essential because the high glucose and central line are major infection risks.
  • Abrupt discontinuation can cause rebound hypoglycemia, so the rate is tapered.
  • If a bag is unavailable, hang 10 percent dextrose to prevent hypoglycemia rather than stopping abruptly.
  • Tubing and the bag are changed every 24 hours, and the bag is never sped up to catch up if behind.

Nursing priorities

  1. Check blood glucose every 4 to 6 hours and treat hyperglycemia per protocol.
  2. Use strict aseptic technique for line care and tubing changes.
  3. Confirm central line placement by x-ray before initiating TPN.
  4. Run TPN on an infusion pump and never abruptly stop or speed up the rate.
  5. Monitor daily weights, intake and output, and electrolytes.

Labs & values

Blood glucose70 to 110 mg/dL goal on TPN
Potassium3.5 to 5.0 mEq/L
Phosphorus3.0 to 4.5 mg/dL
Magnesium1.5 to 2.5 mg/dL
Prealbumin15 to 36 mg/dL for nutritional status

Patient teaching

  • Report any fever, chills, or redness, swelling, or drainage at the catheter site.
  • Do not adjust the pump rate yourself.
  • Keep the dressing clean, dry, and intact to prevent infection.
  • Blood sugar checks are routine while you are on this nutrition.

Red flags: report now

  • Fever, chills, or redness at the insertion site may indicate catheter-related bloodstream infection and must be reported.
  • Never abruptly stop TPN, as it causes rebound hypoglycemia; hang dextrose if the next bag is delayed.
  • Sudden dyspnea, chest pain, or tachycardia may signal air embolism or refeeding complications and is an emergency.
  • Never speed up or slow down to catch up an off-schedule TPN infusion.

References

Clinical references for this topic

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