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Physiological AdaptationGlucose > 250, pH < 7.35

Diabetic Ketoacidosis (DKA)NCLEX cheat sheet

DKA is a life-threatening complication of (usually type 1) diabetes from severe insulin deficiency: the body burns fat for fuel, producing ketones and metabolic acidosis. It is marked by hyperglycemia, ketosis, dehydration, and acidosis, often triggered by illness or missed insulin.

17 key facts 4 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Signs

  • Kussmaul breaths, fruity breath
  • Polyuria, polydipsia, dehydrated
  • ↑ ketones, ↓ HCO3, ↓ pH

Do

  • IV fluids NS first priority
  • Regular insulin IV drip
  • Add dextrose when glucose ~250

Watch

  • K+ drops as insulin given
  • Replace K+, monitor ECG

Report

  • Cerebral edema if too-fast drop
  • Hourly glucose, neuro checks
Key takeaway

Blood glucose usually > 250 mg/dL with ketones in blood/urine

Before you read

Test yourself first: 4 questions

Question 1 of 4

A client with type 1 diabetes is found drowsy, with deep rapid (Kussmaul) respirations and a fruity breath odor. The nurse suspects:

Diabetic Ketoacidosis (DKA) illustrated

How DKA develops: no insulin, glucose trapped in the blood, fat broken down into ketones and acid
How DKA develops: no insulin, glucose trapped in the blood, fat broken down into ketones and acid. Illustration: CinnaRN.

Key points to remember

  • Blood glucose usually > 250 mg/dL with ketones in blood/urine
  • Kussmaul respirations (deep, rapid) and fruity (acetone) breath
  • Polyuria, polydipsia, dehydration, and altered mental status
  • Metabolic acidosis: arterial pH < 7.35, low bicarbonate

Signs & symptoms

  • Kussmaul breaths, fruity breath
  • Polyuria, polydipsia, dehydrated
  • ↑ ketones, ↓ HCO3, ↓ pH

Nursing priorities

  1. IV fluids first — 0.9% normal saline to correct dehydration
  2. Regular insulin IV infusion to lower glucose gradually
  3. Replace potassium — insulin drives K⁺ into cells and can cause hypokalemia
  4. Add dextrose to fluids when glucose nears 200–250 to avoid hypoglycemia

Labs & values

Glucose >250 mg/dL
Arterial pH < 7.35
Positive serum/urine ketones

Patient teaching

  • Never skip insulin, even when sick; check glucose and ketones during illness

Red flags: report now

  • Falling potassium during insulin therapy — monitor and replace before it drops
  • Declining LOC or pH < 7.0 — escalate immediately

References

Clinical references for this topic

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