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Physiological AdaptationNa+ < 135 mEq/L

HyponatremiaNCLEX cheat sheet

Hyponatremia is a serum sodium below 135 mEq/L.

26 key facts 5 practice questions Reviewed Oct 2026
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Causes

  • SIADH, water excess, CHF
  • Diuretics, vomiting, diarrhea
  • Excess hypotonic IV / D5W

Signs

  • Confusion, HA, lethargy
  • Seizures, coma if severe
  • N/V, muscle cramps, ↓ DTRs

Do

  • Restrict fluids if dilutional
  • Hypertonic 3% NaCl → slow, ICU
  • Seizure precautions, safety

Avoid

  • Fast correction → demyelination
  • Daily wts, strict I&O
Red flag to remember

New seizures, worsening confusion, or Na⁺ < 120 mEq/L — notify provider now

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client with severe hyponatremia (serum sodium 116 mEq/L) is receiving 3% hypertonic saline. Which assessment finding requires the nurse to STOP the infusion and notify the provider immediately?

What is hyponatremia?

Sodium drives osmolality and water balance, so a low level pulls water into cells — the brain is most vulnerable, making neurologic changes the central concern. It is classified by fluid status: hypovolemic (vomiting, diarrhea, diuretics), euvolemic (SIADH, excess water intake) or hypervolemic (heart failure, cirrhosis, kidney failure), and the fluid status decides the treatment.

Hyponatremia illustrated

Brain cells swell in hyponatremia and shrink in hypernatremia as water moves
Brain cells swell in hyponatremia and shrink in hypernatremia as water moves. Illustration: CinnaRN.

Key points to remember

  • Neurologic: headache, confusion, lethargy progressing to seizures and coma
  • GI: nausea, vomiting, abdominal cramping
  • Muscle weakness and cramps; possible hypotension if volume-depleted
  • Symptoms depend on how fast the sodium falls: a rapid drop causes brain swelling even at moderately low levels, while a slow fall may cause few symptoms.
  • Fluid-loss hyponatremia is treated with isotonic saline; dilutional hyponatremia (SIADH, fluid overload) is treated with fluid restriction.
  • SIADH retains water, producing concentrated urine and a low serum sodium and osmolality.
  • Higher risk: older adults, patients on thiazide diuretics or SSRIs, and endurance athletes who drink large amounts of plain water.

Common causes

  • SIADH, water excess, CHF
  • Diuretics, vomiting, diarrhea
  • Excess hypotonic IV / D5W

Signs & symptoms

  • Confusion, HA, lethargy
  • Seizures, coma if severe
  • N/V, muscle cramps, ↓ DTRs

Nursing priorities

  1. Restrict fluids when the cause is dilutional/SIADH
  2. Give hypertonic saline (3%) ONLY for severe, symptomatic hyponatremia, slowly
  3. Institute seizure precautions and monitor neuro status closely
  4. Correct sodium slowly — rapid correction risks osmotic demyelination
  5. Monitor daily weight, strict intake and output, and serum sodium as ordered (often every few hours during active correction).

Labs & values

Serum sodium135–145 mEq/L (hyponatremia < 135)
Serum osmolality275–295 mOsm/kg (low in true hyponatremia)
Urine specific gravity 1.005–1.030 (high in SIADH)
135145mEq/L Normal Hyponatremia

Patient teaching

  • Follow a prescribed fluid restriction exactly; spread the allowed fluid across the day and use ice chips or sugar-free gum for thirst.
  • During long exercise, drink fluids that contain electrolytes rather than large amounts of plain water.
  • Report headache, confusion, nausea or muscle cramps, especially when taking a diuretic.

Red flags: report now

  • New seizures, worsening confusion, or Na⁺ < 120 mEq/L — notify provider now
  • Do NOT correct sodium too fast (> 8–12 mEq/L in 24 h)

References

Clinical references for this topic

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