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Acute Pancreatitis — NCLEX Cheat Sheet

↑ lipase/amylase + epigastric pain
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👤 By the CinnaRN Clinical Content Team 🕐 Updated 2026-08-23 🏷️ Physiological Adaptation 🔖 Free to read, print, and share

Also known as: inflamed pancreas · pancreas inflammation · pancreatitis attack

Acute Pancreatitis — clinical diagram
Acute Pancreatitis — clinical diagram. Illustration: Scientific Animations via Wikimedia Commons, CC BY-SA 4.0.
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Use this quick-reference guide to spot, treat, and prevent Acute Pancreatitis on the NCLEX. Keep it handy during review and on exam day!

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📒 The 1-minute cheat sheet

⚠️ Causes

  • Gallstones + alcohol = top 2
  • Autodigestion of pancreas

🩺 Signs

  • Severe epigastric pain → back
  • N/V, fever, ↓ BS, ↑ HR
  • Cullen + Turner sign = severe

🧪 Labs

  • ↑ lipase (specific), ↑ amylase
  • ↓ Ca, ↑ glucose, ↑ WBC

✅ Do

  • NPO, rest pancreas, IV fluids
  • Pain control, NG suction if vomiting
  • No alcohol; low-fat when resume

📚 Acute Pancreatitis — full study notes

The cheat sheet above is your quick recall card. These notes go deeper — what it is, what to do first, what must be reported, and what to teach.

Acute pancreatitis is sudden inflammation of the pancreas caused by premature activation of its own digestive enzymes, leading to autodigestion of the gland. The two leading causes are gallstones and chronic alcohol use. It causes severe epigastric pain that radiates to the back, and can progress to shock, respiratory failure, and multi-organ involvement. Elevated lipase and amylase confirm the diagnosis.
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Key points

Understand these first

Nursing priorities

What to do, in order
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Red flags — report now

Escalate immediately
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Labs & values

Numbers to know
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Patient teaching

What patients must know

❓ Acute Pancreatitis: NCLEX FAQs

What are the priority nursing interventions for Acute Pancreatitis?

Keep the patient NPO to rest the pancreas and reduce enzyme stimulation. Administer IV fluids aggressively to prevent hypovolemia and maintain perfusion. Provide pain control with prescribed opioids and position the patient sitting up leaning forward (fetal/knee-chest comfort position). Monitor for hypocalcemia (Chvostek and Trousseau signs) and respiratory complications.

What are the warning signs of Acute Pancreatitis a nurse must report?

Signs of shock (hypotension, tachycardia) or respiratory distress may indicate severe/hemorrhagic pancreatitis. Cullen or Grey Turner sign signals internal hemorrhage and must be reported immediately. Tetany, positive Chvostek/Trousseau, or seizures indicate dangerous hypocalcemia.

What do I need to know about Acute Pancreatitis for the NCLEX?

Severe, boring epigastric pain radiating to the back is the hallmark, often worse after eating or lying flat and relieved by leaning forward. Lipase is more specific and stays elevated longer than amylase; both rise sharply. Nausea, vomiting, abdominal distention, and fever are common. Cullen sign (periumbilical bruising) and Grey Turner sign (flank bruising) indicate hemorrhagic pancreatitis.

What patient teaching is important for Acute Pancreatitis?

Abstain from alcohol completely, as it is a major trigger and worsens the disease. Follow a low-fat diet and eat small frequent meals when resuming oral intake. Report recurring severe abdominal pain, fever, or vomiting to the provider.

Quick Tip

Severe, boring epigastric pain radiating to the back is the hallmark, often worse after eating or lying flat and relieved by leaning forward.

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