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Physiological AdaptationSudden collapse during labor

Amniotic Fluid EmbolismNCLEX cheat sheet

Amniotic fluid embolism (AFE) is a rare, catastrophic emergency in which amniotic fluid, fetal cells, or debris enter the maternal circulation, triggering an anaphylactoid-type reaction with sudden cardiorespiratory collapse and disseminated intravascular coagulation (DIC).

21 key facts 5 practice questions Reviewed Oct 2026
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Mech

  • Amniotic fluid → maternal circulation
  • Anaphylactoid → cardiorespiratory collapse

Signs

  • Sudden dyspnea, hypoxia, cyanosis
  • Hypotension, cardiac arrest
  • DIC → uncontrolled bleeding

Do

  • Call code, high-flow O2, intubate
  • CPR, fluids, blood products
  • Left lateral tilt, prep emergent delivery

Report

  • High mortality → rapid response
Red flag to remember

Report sudden dyspnea, hypotension, cyanosis, or cardiovascular collapse in labor or postpartum immediately.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A nurse assesses the amniotic fluid of a laboring client and notes it is green and thick. What does this finding indicate, and what is the priority concern?

What is amniotic fluid embolism?

It usually occurs during labor, delivery, or immediately postpartum. Onset is abrupt and mortality is high, so immediate resuscitation is required.

Key points to remember

  • Classic triad: sudden hypoxia/respiratory distress, hypotension/cardiovascular collapse, and coagulopathy (DIC).
  • Early signs may include acute dyspnea, restlessness, chest pain, cyanosis, and a feeling of impending doom.
  • DIC causes uncontrolled bleeding from the uterus, IV sites, and incisions.
  • Treatment is supportive: aggressive oxygenation/ventilation, circulatory support, and correction of coagulopathy with blood products.
  • Care requires a rapid multidisciplinary response and often ICU-level support.
  • If undelivered, emergent delivery of the fetus is performed to improve maternal resuscitation.

Signs & symptoms

  • Sudden dyspnea, hypoxia, cyanosis
  • Hypotension, cardiac arrest
  • DIC → uncontrolled bleeding

Nursing priorities

  1. Call a rapid response/code and provide immediate high-flow oxygen and prepare for intubation/CPR.
  2. Position appropriately, establish large-bore IV access, and give fluids/vasopressors as ordered.
  3. Anticipate and administer blood products (PRBCs, FFP, platelets, cryoprecipitate) for DIC.
  4. Continuously monitor maternal vitals, oxygenation, and fetal status; prepare for emergent delivery.
  5. Provide emotional support to the family during the emergency.

Labs & values

Coagulation studies of DIC: prolonged PT/PTT, low fibrinogen, low platelets, elevated D-dimer
ABG: profound hypoxemia

Patient teaching

  • Because AFE is sudden and unpredictable, teaching focuses on informing the family during/after the emergency.
  • Explain interventions and monitoring to support the family during the crisis.

Red flags: report now

  • Report sudden dyspnea, hypotension, cyanosis, or cardiovascular collapse in labor or postpartum immediately.
  • Report uncontrolled bleeding/oozing from IV sites or incisions (DIC).
  • Report acute loss of consciousness or cardiac arrest and begin resuscitation.

References

Clinical references for this topic

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