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Physiological AdaptationRefractory hypoxemia

ARDSNCLEX cheat sheet

Acute respiratory distress syndrome is a severe inflammatory lung injury causing increased alveolar-capillary permeability, noncardiogenic pulmonary edema, and collapse of the alveoli, leading to refractory hypoxemia.

21 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Signs

  • Severe dyspnea, ↓ O₂ despite O₂
  • Tachypnea, retractions, anxiety
  • Bilateral infiltrates (white-out)

Labs

  • PaO₂/FiO₂ ratio < 300
  • Resp acidosis, low PaO₂

Do

  • Intubate + mech ventilation
  • PEEP, low tidal volume
  • Prone positioning, treat cause

Causes

  • Sepsis, aspiration, trauma
Key takeaway

Refractory hypoxemia that does not respond to increasing oxygen is the defining feature.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A client with a stroke has expressive (Broca's) aphasia. Which communication approach is most appropriate?

What is ards?

It develops 12 to 48 hours after an insult such as sepsis, aspiration, trauma, or pancreatitis. The hallmark is hypoxemia that does not improve with supplemental oxygen.

ARDS illustrated

ARDS: fluid-filled alveoli, hyaline membranes and collapsed air sacs vs normal alveoli
ARDS: fluid-filled alveoli, hyaline membranes and collapsed air sacs vs normal alveoli. Illustration: CinnaRN.

Key points to remember

  • Refractory hypoxemia that does not respond to increasing oxygen is the defining feature.
  • Severe dyspnea, tachypnea, and use of accessory muscles develop rapidly.
  • Chest x-ray shows bilateral diffuse white-out infiltrates with no cardiac cause.
  • Decreased lung compliance makes the lungs stiff and hard to ventilate.
  • Pulmonary capillary wedge pressure is normal or low, distinguishing it from cardiogenic pulmonary edema.
  • ARDS commonly progresses to multi-organ dysfunction and carries high mortality.

Common causes

  • Sepsis, aspiration, trauma

Signs & symptoms

  • Severe dyspnea, ↓ O₂ despite O₂
  • Tachypnea, retractions, anxiety
  • Bilateral infiltrates (white-out)

Nursing priorities

  1. Support oxygenation and prepare for intubation and mechanical ventilation with PEEP.
  2. Use low tidal volume lung-protective ventilation to prevent further barotrauma.
  3. Consider prone positioning to improve oxygenation and ventilation-perfusion matching.
  4. Treat the underlying cause, such as sepsis or aspiration, aggressively.
  5. Monitor ABGs, hemodynamics, and oxygenation continuously, and provide sedation as needed.

Labs & values

ABG: severe hypoxemia with PaO2/FiO2 ratio <300 (mild) to <100 (severe)
Refractory hypoxemia: low PaO2 despite high oxygen
PCWP normal or low (<18 mmHg), unlike cardiogenic edema

Red flags: report now

  • Worsening hypoxemia despite high FiO2 and PEEP indicates deterioration toward failure.
  • Sudden drop in oxygen saturation or chest asymmetry on a ventilator may signal pneumothorax from barotrauma.
  • Signs of multi-organ failure (oliguria, hypotension, altered mentation) require immediate escalation.

References

Clinical references for this topic

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