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Physiological AdaptationGluten → villi destruction

Celiac DiseaseNCLEX cheat sheet

Celiac disease is an autoimmune disorder in which ingesting gluten (found in wheat, barley, and rye) triggers immune-mediated damage to the small-intestinal villi, causing malabsorption.

25 key facts 3 practice questions Reviewed Oct 2026
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Mechanism

  • Autoimmune rxn to gluten
  • Damages small bowel villi

Signs

  • Steatorrhea: pale, foul, fatty
  • Bloating, weight loss, anemia
  • Dermatitis herpetiformis rash

Avoid

  • NO wheat, barley, rye (BROW)
  • Check labels, hidden gluten

Do

  • OK: rice, corn, quinoa, oats
  • Lifelong gluten-free diet
Red flag to remember

Report continued symptoms or weight loss despite a gluten-free diet (possible hidden gluten or refractory disease).

Before you read

Test yourself first: 3 questions

Question 1 of 3

The nurse is assessing a newborn for Hirschsprung disease. Which finding in the first 48 hours of life is most suggestive of this disorder?

What is celiac disease?

Memory aid for forbidden grains: BROW (Barley, Rye, Oats-if contaminated, Wheat). The only treatment is a strict, lifelong gluten-free diet.

Key points to remember

  • Gluten exposure flattens intestinal villi, causing malabsorption with steatorrhea (bulky, foul, fatty, floating stools), weight loss, bloating, and fatigue.
  • Malabsorption leads to deficiencies of iron, folate, vitamin B12, fat-soluble vitamins (A, D, E, K), and calcium, causing anemia and osteoporosis.
  • The cornerstone of treatment is a lifelong strict gluten-free diet that excludes wheat, barley, and rye.
  • Safe grains include rice, corn, quinoa, and certified gluten-free oats; patients must read labels for hidden gluten.
  • Diagnosis uses serology (tissue transglutaminase IgA, anti-endomysial antibodies) and small-bowel biopsy showing villous atrophy.
  • In children, untreated disease causes failure to thrive; dermatitis herpetiformis is a related itchy blistering rash.

Signs & symptoms

  • Steatorrhea: pale, foul, fatty
  • Bloating, weight loss, anemia
  • Dermatitis herpetiformis rash

Nursing priorities

  1. Teach and reinforce a strict lifelong gluten-free diet and meticulous label reading.
  2. Assess for and address nutritional deficiencies (iron, folate, B12, calcium, vitamin D) and monitor growth in children.
  3. Monitor hydration and electrolyte balance during active diarrhea/malabsorption.
  4. Refer to a dietitian and celiac support resources for sustainable adherence.
  5. Watch for accidental gluten exposure and reinforce avoidance of cross-contamination.

Labs & values

Tissue transglutaminase (tTG-IgA): positive in celiac
Anti-endomysial antibodies (EMA): positive
Hgb low (iron/folate deficiency anemia)
Vitamin D, B12, folate, iron may be low

Patient teaching

  • Strictly avoid all wheat, barley, and rye, including hidden sources in sauces, soups, processed foods, and medications.
  • Choose naturally gluten-free foods (rice, corn, quinoa, potatoes, fresh meats, fruits, vegetables) and certified gluten-free products.
  • Prevent cross-contamination with separate utensils, toasters, and preparation surfaces.
  • Read every label every time, since ingredients change, and the diet is lifelong.

Red flags: report now

  • Report continued symptoms or weight loss despite a gluten-free diet (possible hidden gluten or refractory disease).
  • Report signs of severe deficiency: bone pain/fractures (osteoporosis), neuropathy (B12), or bleeding (vitamin K).
  • Never reintroduce gluten 'just to test'; even small amounts cause damage.

References

Clinical references for this topic

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