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Physiological Adaptation↑ cortisol → ↑ Na, ↓ K, ↑ glucose

Cushing SyndromeNCLEX cheat sheet

Cushing syndrome is a condition of excess cortisol, most often caused by chronic corticosteroid (glucocorticoid) therapy, and less often by a pituitary or adrenal tumor.

24 key facts 5 practice questions Reviewed Oct 2026
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Causes

  • Chronic steroids #1 cause
  • Pituitary/adrenal tumor (ACTH)

Signs

  • Moon face, buffalo hump, truncal
  • Purple striae, thin skin, bruising
  • HTN, weakness, hirsutism

Labs

  • ↑ Na, ↓ K, ↑ glucose
  • ↑ cortisol, dexamethasone test

Do

  • Low Na, ↑ K, ↑ protein diet
  • Infection precautions, skin care
  • Taper steroids; never stop abrupt
Red flag to remember

Report signs of infection promptly, as immunosuppression can mask and worsen infections quickly.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client has Cushing syndrome from chronic high cortisol. Which findings does the nurse expect on assessment?

What is cushing syndrome?

Excess cortisol causes fat redistribution, muscle wasting, glucose intolerance, and immune suppression. Memory aid: 'too much steroid' produces a moon face, buffalo hump, and truncal obesity. It is essentially the opposite picture of Addison disease.

Cushing Syndrome illustrated

Cushing syndrome: excess cortisol from the adrenal glands
Cushing syndrome: excess cortisol from the adrenal glands. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Classic features are moon face, buffalo hump, truncal/central obesity with thin extremities, and purple striae on the abdomen.
  • Excess cortisol causes hyperglycemia, hypertension, and sodium and water retention with edema.
  • Potassium and calcium are lost, leading to hypokalemia and bone loss/osteoporosis with fracture risk.
  • Skin is thin and fragile, bruises easily, and wounds heal slowly; immunosuppression raises infection risk.
  • Mood changes, muscle weakness from protein catabolism, and hirsutism in women are common.

Common causes

  • Chronic steroids #1 cause
  • Pituitary/adrenal tumor (ACTH)

Signs & symptoms

  • Moon face, buffalo hump, truncal
  • Purple striae, thin skin, bruising
  • HTN, weakness, hirsutism

Nursing priorities

  1. Monitor blood glucose, blood pressure, weight, and intake/output, and watch for fluid overload.
  2. Protect from infection with meticulous hygiene and protect fragile skin from injury and breakdown.
  3. Provide a diet low in sodium and high in protein, potassium, and calcium.
  4. Prevent falls and fractures because of osteoporosis and muscle weakness.
  5. For patients on steroids, never stop the medication abruptly; taper as ordered.

Labs & values

Cortisol: elevated (normal AM6-23 mcg/dL)
Glucose: elevated (normal fasting70-100 mg/dL)
Potassium: low (normal3.5-5.0 mEq/L)
623mcg/dL Normal

Patient teaching

  • Take corticosteroids exactly as prescribed and never stop them suddenly.
  • Wear medical alert identification and carry information about steroid use.
  • Report signs of infection, easy bruising, and significant weight gain or swelling.

Red flags: report now

  • Report signs of infection promptly, as immunosuppression can mask and worsen infections quickly.
  • Never abruptly discontinue chronic corticosteroids; abrupt withdrawal can cause acute adrenal crisis.
  • Report severe hypertension, crushing chest pain, or signs of heart failure from fluid overload.

References

Clinical references for this topic

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