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Physiological AdaptationTubal → unilateral pain + shock

Ectopic PregnancyNCLEX cheat sheet

Ectopic pregnancy is implantation of a fertilized ovum outside the uterine cavity, most commonly in a fallopian tube.

22 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Define

  • Implant outside uterus (tube)
  • PID, prior ectopic = risk

Signs

  • Unilateral lower abd pain
  • Spotting, missed period, +hCG

Rupture

  • Sudden sharp pain, ↓ BP, shock
  • Referred shoulder pain (bleed)

Treat

  • Methotrexate if early/unruptured
  • Surgery if ruptured, large-bore IV
Key takeaway

Unilateral lower abdominal or pelvic pain with a missed period is the classic presentation.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A client at 7 weeks gestation reports sudden, sharp, one-sided lower abdominal pain and scant vaginal spotting. Her serum beta-hCG is lower than expected for gestational age. Which complication should the nurse suspect first?

What is ectopic pregnancy?

As the embryo grows, it can rupture the tube, causing life-threatening internal hemorrhage. Risk factors include prior pelvic inflammatory disease, tubal surgery, prior ectopic, and IUD use. The classic triad is unilateral lower abdominal pain, amenorrhea or a missed period, and vaginal bleeding (often scant and dark).

Ectopic Pregnancy illustrated

Ectopic Pregnancy — medical illustration
Ectopic Pregnancy — medical illustration. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Unilateral lower abdominal or pelvic pain with a missed period is the classic presentation.
  • Vaginal bleeding is often scant, dark, and intermittent rather than a normal period.
  • Serum hCG levels rise more slowly than in a normal intrauterine pregnancy.
  • Tubal rupture causes sudden, severe pain and signs of internal hemorrhage and shock.
  • Referred shoulder pain (Kehr sign) can occur from blood irritating the diaphragm after rupture.

Signs & symptoms

  • Unilateral lower abd pain
  • Spotting, missed period, +hCG

Nursing priorities

  1. Assess pain, vaginal bleeding, and vital signs for signs of rupture and hypovolemic shock.
  2. Establish IV access and monitor for shock; prepare for fluid and blood replacement if rupture is suspected.
  3. Administer methotrexate as prescribed for an early, unruptured ectopic to dissolve the pregnancy.
  4. Prepare the patient for emergency surgery (salpingostomy or salpingectomy) if rupture occurs.
  5. Provide emotional support for pregnancy loss and explain the impact on future fertility.

Labs & values

Beta-hCG: rises abnormally slowly (does not roughly double every48 hours as in normal pregnancy)
Hemoglobin/hematocrit: fall with internal bleeding (Hgb12-16 g/dL, Hct 36-46%)
Blood type and Rh (Rh-negative patients need Rho(D) immune globulin)

Patient teaching

  • Return immediately for sudden severe abdominal or shoulder pain, dizziness, or fainting.
  • If treated with methotrexate, avoid alcohol, folic acid, and NSAIDs, and attend all follow-up hCG checks.
  • Discuss future pregnancy plans, as one ectopic raises the risk of another.

Red flags: report now

  • Sudden severe abdominal pain, shoulder pain, dizziness, or signs of shock indicate tubal rupture, a surgical emergency.
  • Report falling blood pressure, rising heart rate, and pallor, which signal internal hemorrhage.
  • If methotrexate is given, the patient must avoid folic acid supplements and alcohol, which interfere with the drug.
  • Report a hCG level that plateaus or rises abnormally rather than declining after treatment.

References

Clinical references for this topic

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