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Physiological AdaptationGradual scrotal pain + fever

EpididymitisNCLEX cheat sheet

Epididymitis is inflammation or infection of the epididymis, the coiled tube behind the testis.

26 key facts Reviewed Oct 2026
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Signs

  • Gradual onset scrotal pain
  • Fever, dysuria, discharge
  • +Prehn's: pain ↓ when lifted

Causes

  • STI (young): chlamydia, gonorrhea
  • E. coli (older/UTI source)

Do

  • Antibiotics, treat partner
  • Scrotal elevation, ice, rest
  • Rule out torsion FIRST
Red flag to remember

Report sudden severe pain, a high-riding testicle, or pain not relieved by scrotal elevation (possible torsion).

What is epididymitis?

In younger sexually active men it is usually from sexually transmitted organisms (chlamydia, gonorrhea); in older men it is more often from urinary tract bacteria (E. coli). It causes gradual scrotal pain and swelling and must be distinguished from testicular torsion.

Key points to remember

  • Pain typically develops gradually (vs. the sudden onset of torsion) and is accompanied by scrotal swelling, redness, warmth, and often fever and dysuria.
  • Elevating the scrotum tends to RELIEVE the pain (positive Prehn sign), and the cremasteric reflex is usually intact, helping differentiate it from torsion.
  • Treatment is antibiotics targeting the likely organism, with NSAIDs, scrotal support, and rest.
  • If STI-related, the patient's sexual partner(s) must also be treated and STIs reported as required.
  • Pyuria and bacteriuria are often present, unlike in torsion.
  • Complications include abscess, chronic epididymitis, and impaired fertility if untreated.

Common causes

  • STI (young): chlamydia, gonorrhea
  • E. coli (older/UTI source)

Signs & symptoms

  • Gradual onset scrotal pain
  • Fever, dysuria, discharge
  • +Prehn's: pain ↓ when lifted

Nursing priorities

  1. Distinguish epididymitis from torsion; if onset is sudden and severe, treat as an emergency until torsion is excluded.
  2. Administer prescribed antibiotics and ensure completion of the full course.
  3. Promote comfort with scrotal elevation/support, ice, NSAIDs, and rest.
  4. Educate on STI prevention and partner treatment when applicable.
  5. Monitor temperature and assess for worsening swelling or abscess formation.

Labs & values

WBC:5,000-10,000/mm3 (may be elevated)
Urinalysis often shows pyuria and bacteriuria
STI testing (NAAT) positive for chlamydia/gonorrhea in younger men

Patient teaching

  • Take the full course of antibiotics even after symptoms improve.
  • Use scrotal support and ice, rest, and take NSAIDs for pain and inflammation.
  • If sexually transmitted, ensure partners are treated and avoid intercourse until cleared.
  • Return for sudden severe pain, high fever, or worsening swelling.

Red flags: report now

  • Report sudden severe pain, a high-riding testicle, or pain not relieved by scrotal elevation (possible torsion).
  • Report high fever, increasing swelling, or fluctuant mass suggesting abscess.
  • Report failure to improve after starting antibiotics.

References

Clinical references for this topic

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