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Physiological AdaptationUric acid → big toe pain

GoutNCLEX cheat sheet

Gout is a metabolic disorder in which excess uric acid forms crystals that deposit in joints, causing acute, intensely painful inflammation.

23 key facts 1 practice questions Reviewed Oct 2026
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Signs

  • Sudden severe pain great toe
  • Red, hot, swollen joint, tophi
  • ↑ uric acid > 6.8 mg/dL

Meds

  • Acute: colchicine, NSAIDs
  • Chronic: allopurinol (not in flare)
  • Colchicine → diarrhea, hold if severe

Avoid

  • Purines: organ meat, shellfish
  • Alcohol (beer), high-fructose drinks

Teach

  • ↑ fluids 2-3 L/day
  • Low-purine diet, cherries help
Key takeaway

Acute attacks cause sudden, severe pain, redness, warmth, and swelling, classically in the great toe.

Before you read

Test yourself first: 1 question

Question 1 of 1

A client with gout is admitted with an acutely painful, red, swollen great toe. Which dietary instruction should the nurse provide to help prevent future attacks?

What is gout?

The classic site is the great toe (podagra). It results from overproduction or underexcretion of uric acid and is triggered by purine-rich foods, alcohol, and certain diuretics.

Gout illustrated

Gout: urate crystals inflaming a joint
Gout: urate crystals inflaming a joint. Illustration: www.scientificanimations.com/ via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Acute attacks cause sudden, severe pain, redness, warmth, and swelling, classically in the great toe.
  • The affected joint is so tender that even the weight of a bed sheet is intolerable.
  • Tophi are hard, painless urate crystal deposits found in chronic gout under the skin and in joints.
  • Triggers include purine-rich foods (organ meats, shellfish, red meat), alcohol (especially beer), and dehydration.
  • Elevated serum uric acid supports the diagnosis, confirmed by urate crystals in joint fluid.
  • Chronic gout can lead to joint damage and urate kidney stones.

Signs & symptoms

  • Sudden severe pain great toe
  • Red, hot, swollen joint, tophi
  • ↑ uric acid > 6.8 mg/dL

Nursing priorities

  1. Administer NSAIDs, colchicine, or corticosteroids during an acute attack as ordered.
  2. Rest and immobilize the affected joint and protect it from pressure, including bed linens.
  3. Encourage increased fluid intake (2 to 3 liters daily) to flush uric acid and prevent stones.
  4. Administer urate-lowering drugs (allopurinol) for prevention, NOT during an acute attack.
  5. Apply cold to the inflamed joint to reduce pain and swelling.

Labs & values

Serum uric acid:3.4 to 7.0 mg/dL men, 2.4 to 6.0 mg/dL women (elevated in gout)
ESR:0 to 20 mm/hr (elevated during acute attack)
WBC:5,000 to 10,000/mm3 (may be elevated)

Patient teaching

  • Avoid high-purine foods such as organ meats, red meat, shellfish, and sardines, and limit alcohol.
  • Drink 2 to 3 liters of fluid daily to prevent uric acid stones.
  • Take allopurinol regularly for prevention but never to treat an active attack, and report any rash.

Red flags: report now

  • Flank pain and hematuria suggest uric acid kidney stones and need prompt evaluation.
  • A rash or signs of hypersensitivity with allopurinol can progress to severe skin reactions; stop and report.
  • Never start allopurinol during an acute attack, as it can worsen and prolong the flare.

References

Clinical references for this topic

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