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Physiological AdaptationNa+ > 145 mEq/L

HypernatremiaNCLEX cheat sheet

Hypernatremia is a serum sodium above 145 mEq/L, almost always reflecting a water deficit relative to sodium (too little water, not too much salt).

24 key facts 4 practice questions Reviewed Oct 2026
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Causes

  • Water loss: fever, diarrhea, DI
  • ↑ Na intake, ↓ water access

Signs

  • Thirst, dry mucous membranes
  • Restless → confusion → seizures
  • FRIED: flushed, restless, edema, ↓UOP

Do

  • Hypotonic fluids (0.45% NS) slowly
  • Encourage water, monitor neuro/I&O

Avoid

  • Correct SLOW → cerebral edema if fast
  • Limit high-sodium foods
Red flag to remember

New or worsening seizures, sudden decline in level of consciousness, or coma - report immediately and protect airway.

Before you read

Test yourself first: 4 questions

Question 1 of 4

A client with hypernatremia (serum sodium 152 mEq/L) is being treated. Which intervention does the nurse anticipate?

What is hypernatremia?

It matters because water shifts out of brain cells, causing dangerous neurologic changes. Common causes include dehydration, decreased water intake (older adults, tube-fed clients), diabetes insipidus, watery diarrhea, and excess salt intake. Memory aid: think FRIED - Fever/Flushed skin, Restless/agitated, Increased fluid retention/Increased BP, Edema (peripheral/pitting), Decreased urine output/Dry mouth.

Hypernatremia illustrated

Brain cells swell in hyponatremia and shrink in hypernatremia as water moves
Brain cells swell in hyponatremia and shrink in hypernatremia as water moves. Illustration: CinnaRN.

Key points to remember

  • Sodium pulls water with it, so high sodium causes intracellular dehydration, especially of brain cells.
  • Neurologic signs dominate: restlessness, agitation, irritability, lethargy, twitching, seizures, and coma in severe cases.
  • Thirst is an early and strong symptom in clients who are alert and able to perceive it.
  • Mucous membranes are dry and sticky, the tongue is rough and red, and skin may be flushed and warm.
  • In hypervolemic hypernatremia (salt excess) signs include edema, weight gain, and elevated blood pressure.
  • In hypovolemic hypernatremia (water loss) signs include low urine output, weak pulse, and postural hypotension.

Common causes

  • Water loss: fever, diarrhea, DI
  • ↑ Na intake, ↓ water access

Signs & symptoms

  • Thirst, dry mucous membranes
  • Restless → confusion → seizures
  • FRIED: flushed, restless, edema, ↓UOP

Nursing priorities

  1. Monitor neurologic status frequently (level of consciousness, orientation, seizure precautions) as the priority safety concern.
  2. Restore fluid balance, typically with hypotonic IV fluids (0.45% NaCl) or isotonic fluids per order, and oral water if able.
  3. Lower serum sodium slowly, no faster than about 0.5 mEq/L per hour, to prevent cerebral edema.
  4. Monitor serum sodium, intake and output, daily weights, and offer/encourage water for clients who cannot get it themselves.
  5. Restrict dietary sodium and hold sodium-containing fluids when the cause is salt excess.

Labs & values

Serum sodium normal135-145 mEq/L; hypernatremia is greater than 145 mEq/L
Serum osmolality normal275-295 mOsm/kg; elevated with hypernatremia
135145mEq/L Normal Hypernatremia

Patient teaching

  • Drink adequate water daily, especially older adults, athletes, and anyone with fever or diarrhea.
  • Read labels and limit high-sodium processed foods, canned soups, and salty snacks.
  • Report excessive thirst, dry mouth, confusion, or decreased urination to the provider.

Red flags: report now

  • New or worsening seizures, sudden decline in level of consciousness, or coma - report immediately and protect airway.
  • Correcting sodium too quickly can cause cerebral edema, so an abrupt large drop in serum sodium is an emergency.
  • Persistent high urine output with rising sodium suggests diabetes insipidus and needs urgent provider notification.

References

Clinical references for this topic

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