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Physiological Adaptation↓ TSH, ↑ T3/T4 → hypermetabolic

Hyperthyroidism (Graves Disease)NCLEX cheat sheet

Hyperthyroidism is excess thyroid hormone (T3/T4) that speeds up metabolism; Graves disease is the most common cause, an autoimmune disorder where antibodies stimulate the thyroid.

23 key facts 5 practice questions Reviewed Oct 2026
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Signs

  • Wt loss, ↑ HR, heat intolerance
  • Exophthalmos, goiter, tremor
  • Diarrhea, anxious, insomnia

Labs

  • ↓ TSH, ↑ free T4/T3
  • TSI antibodies + in Graves

Meds

  • PTU, methimazole block synthesis
  • Beta-blockers → control HR/tremor
  • Radioactive iodine, thyroidectomy

Teach

  • Cool room, ↑ calorie diet
  • Report fever/chest pain = storm
Red flag to remember

Report fever, severe tachycardia, agitation, or altered mental status, which signal thyroid storm, a life-threatening emergency.

Before you read

Test yourself first: 5 questions

Question 1 of 5

The nurse reviews lab work for a client with primary hyperthyroidism (Graves disease). Which result is consistent with this diagnosis?

What is hyperthyroidism (graves disease)?

Everything 'speeds up': heart rate, metabolism, GI motility, and energy expenditure. Memory aid: think 'everything HIGH and FAST' (think of someone over-caffeinated). Graves is classically associated with bulging eyes (exophthalmos) and goiter.

Hyperthyroidism (Graves Disease) illustrated

Hyperthyroidism (Graves Disease) — medical illustration
Hyperthyroidism (Graves Disease) — medical illustration. Illustration: BruceBlaus via Wikimedia Commons, CC BY 3.0.

Key points to remember

  • Signs include tachycardia, palpitations, hypertension, heat intolerance, diaphoresis, and warm moist skin.
  • Weight loss despite increased appetite, frequent loose stools, and fine hand tremor are characteristic.
  • Patients are restless, anxious, irritable, and may have insomnia and difficulty concentrating.
  • Exophthalmos (protruding eyeballs) and goiter (enlarged thyroid) are hallmark findings in Graves disease.
  • TSH is low while free T3 and T4 are elevated due to feedback suppression of the pituitary.
  • Untreated disease increases risk for atrial fibrillation, osteoporosis, and thyroid storm.

Signs & symptoms

  • Wt loss, ↑ HR, heat intolerance
  • Exophthalmos, goiter, tremor
  • Diarrhea, anxious, insomnia

Nursing priorities

  1. Promote a cool, calm, quiet, low-stimulation environment to reduce metabolic demand.
  2. Provide a high-calorie, high-protein diet with frequent meals to offset hypermetabolism; avoid caffeine and stimulants.
  3. Administer antithyroid drugs (methimazole, PTU), beta blockers for symptom control, and iodine preparations as ordered.
  4. Monitor cardiac status, vital signs, weight, and protect bulging eyes with artificial tears, eye shields, and elevated head of bed.
  5. After radioactive iodine therapy, teach radiation safety precautions and monitor for resulting hypothyroidism.

Labs & values

TSH: low (normal0.4-4.0 mIU/L)
Free T4: elevated (normal0.8-1.8 ng/dL)
Free T3: elevated (normal2.3-4.2 pg/mL)
0.44.0mIU/L Normal

Patient teaching

  • Take antithyroid medication consistently and report sore throat, fever, or signs of infection (risk of agranulocytosis).
  • Report any rapid weight changes, palpitations, or worsening eye symptoms to the provider.
  • After radioactive iodine, lifelong thyroid replacement is often needed because of resulting hypothyroidism.

Red flags: report now

  • Report fever, severe tachycardia, agitation, or altered mental status, which signal thyroid storm, a life-threatening emergency.
  • Report new or worsening chest pain, irregular pulse, or signs of atrial fibrillation.
  • Never abruptly stop antithyroid medication, as this can precipitate thyroid storm.

References

Clinical references for this topic

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