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Physiological AdaptationInfected heart valves/lining

Infective EndocarditisNCLEX cheat sheet

Infective endocarditis is an infection of the inner lining of the heart and the heart valves, usually bacterial, that forms vegetations on valve surfaces.

23 key facts 2 practice questions Reviewed Oct 2026
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Signs

  • Fever, new murmur, chills
  • Janeway lesions, Osler nodes
  • Splinter hemorrhages, Roth spots
  • Petechiae, fatigue, weight loss

Report

  • Embolism → stroke, MI, kidney
  • HF from valve damage

Do

  • Blood cultures, then IV abx 4-6wk
  • Monitor for emboli signs

Teach

  • Prophylactic abx before dental
  • Good oral hygiene
Red flag to remember

New neurologic deficits, chest pain, or limb pain and pallor signal embolization and must be reported immediately.

Before you read

Test yourself first: 2 questions

Question 1 of 2

A client with infective endocarditis is being monitored for embolic complications. Which finding should the nurse report to the provider immediately?

What is infective endocarditis?

These vegetations can destroy valves and break off as septic emboli that travel to the brain, lungs, kidneys, and extremities. Risk factors include IV drug use, prosthetic valves, recent invasive or dental procedures, and pre-existing valve disease.

Infective Endocarditis illustrated

Infective Endocarditis — medical illustration
Infective Endocarditis — medical illustration. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Classic findings include fever, a new or changing heart murmur, and fatigue.
  • Peripheral signs from emboli include Janeway lesions, Osler nodes, splinter hemorrhages, and Roth spots in the eyes.
  • Septic emboli can cause stroke, pulmonary embolism, splenic infarct, and limb ischemia.
  • Blood cultures identify the causative organism and guide antibiotic therapy.
  • IV drug use, prosthetic valves, and recent dental or invasive procedures are major risk factors.

Signs & symptoms

  • Fever, new murmur, chills
  • Janeway lesions, Osler nodes
  • Splinter hemorrhages, Roth spots
  • Petechiae, fatigue, weight loss

Nursing priorities

  1. Obtain blood cultures from multiple sites before starting antibiotics.
  2. Administer long-term IV antibiotic therapy exactly as scheduled, often for 4 to 6 weeks.
  3. Monitor for signs of embolization to the brain, lungs, kidneys, and extremities.
  4. Assess for and monitor signs of heart failure from valve damage.
  5. Monitor temperature and response to therapy and maintain IV line integrity for prolonged access.

Labs & values

Blood cultures: positive identifying the organism (drawn before antibiotics)
WBC: elevated above normal5,000-10,000/mm3
ESR and CRP: elevated indicating inflammation

Patient teaching

  • Complete the entire course of IV antibiotics even after symptoms improve to fully clear the infection.
  • Take prophylactic antibiotics before dental and invasive procedures if you have a prosthetic valve or prior endocarditis.
  • Maintain good oral hygiene and report any recurrence of fever, fatigue, or night sweats.

Red flags: report now

  • New neurologic deficits, chest pain, or limb pain and pallor signal embolization and must be reported immediately.
  • Signs of acute heart failure such as new crackles, dyspnea, or worsening murmur require urgent escalation.
  • Persistent fever despite antibiotics may indicate treatment failure or abscess and must be reported.

References

Clinical references for this topic

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