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Physiological AdaptationMicrocytic, ↓ferritin

Iron-Deficiency AnemiaNCLEX cheat sheet

Iron-deficiency anemia is the most common anemia, caused by inadequate iron to make hemoglobin, producing small, pale red cells.

25 key facts 5 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Causes

  • blood loss, ↓intake, menstruation
  • GI bleed, pregnancy, malabsorb

Signs

  • pallor, fatigue, tachycardia
  • spoon nails, pica, glossitis

Labs

  • microcytic hypochromic RBC
  • ↓ferritin, ↓Hgb, ↑TIBC

Teach

  • iron + vit C (↑absorption)
  • take empty stomach, expect dark stool
  • IM iron = Z-track, no massage
  • liquid iron via straw (stains teeth)
Red flag to remember

Report tachycardia, chest pain, or marked dyspnea that signals cardiac compensation from severe anemia.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A nurse evaluates a client with vitamin B12 deficiency anemia. Which manifestation distinguishes this from iron deficiency anemia?

What is iron-deficiency anemia?

Common causes are chronic blood loss (GI bleed, heavy menses), poor dietary intake, malabsorption, and pregnancy. It matters because low oxygen-carrying capacity causes fatigue and, if severe, cardiac strain.

Iron-Deficiency Anemia illustrated

Red cells: normal vs small pale (iron deficiency) vs large oval (B12 deficiency)
Red cells: normal vs small pale (iron deficiency) vs large oval (B12 deficiency). Illustration: CinnaRN.

Key points to remember

  • Red cells are microcytic and hypochromic (small and pale).
  • Classic signs include fatigue, pallor, weakness, dyspnea on exertion, and tachycardia.
  • Pica (craving ice, dirt, or clay) and spoon-shaped, brittle nails (koilonychia) are characteristic.
  • Glossitis (smooth, sore, beefy-red tongue) and cheilosis (cracked mouth corners) may occur.
  • In adults, a new iron-deficiency anemia is GI blood loss until proven otherwise.
  • Ferritin (iron stores) is low and is the earliest lab to drop.

Common causes

  • blood loss, ↓intake, menstruation
  • GI bleed, pregnancy, malabsorb

Signs & symptoms

  • pallor, fatigue, tachycardia
  • spoon nails, pica, glossitis

Nursing priorities

  1. Assess for and identify the source of blood loss, including checking stool for occult blood.
  2. Administer prescribed oral iron with vitamin C or orange juice on an empty stomach to enhance absorption.
  3. Give IM iron by Z-track technique to prevent staining and tissue irritation; never massage the site.
  4. Balance activity with rest and space care to reduce oxygen demand and fatigue.
  5. Monitor reticulocyte count, which should rise within a week of effective therapy.

Labs & values

Hemoglobin (normal12-16 g/dL female, 14-18 g/dL male) decreased
Hematocrit (normal36-46% female, 42-52% male) decreased
Serum ferritin (normal12-150 ng/mL) decreased
MCV (normal80-100 fL) decreased
1216g/dL Normal

Patient teaching

  • Take oral iron with vitamin C or juice and avoid taking it with milk, antacids, tea, or coffee.
  • Iron turns stools dark/tarry-black and may cause constipation; increase fluids and fiber.
  • Eat iron-rich foods such as red meat, liver, leafy greens, beans, and fortified cereals; use a straw for liquid iron to protect teeth.

Red flags: report now

  • Report tachycardia, chest pain, or marked dyspnea that signals cardiac compensation from severe anemia.
  • Report active or worsening GI bleeding (melena, hematemesis, bright red rectal bleeding).
  • Hemoglobin below the transfusion threshold or rapidly falling requires escalation.

References

Clinical references for this topic

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