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Physiological AdaptationCoronary aneurysm = top risk

Kawasaki DiseaseNCLEX cheat sheet

Kawasaki disease is an acute systemic vasculitis of unknown cause that primarily affects children under 5 and is the leading cause of acquired heart disease in children.

26 key facts 4 practice questions Reviewed Oct 2026
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Signs

  • Fever > 5 days, unresponsive
  • Strawberry tongue, cracked lips
  • Conjunctivitis, rash, peeling palms
  • Cervical lymphadenopathy, edema

Meds

  • IVIG + high-dose ASPIRIN
  • Aspirin OK here (anti-platelet)

Do

  • Echocardiogram to monitor heart
  • Delay live vaccines 11mo post-IVIG

Report

  • Coronary artery aneurysm
  • Chest pain, MI signs
Key takeaway

A high fever lasting 5 or more days that is unresponsive to antipyretics is the hallmark.

Before you read

Test yourself first: 4 questions

Question 1 of 4

A nurse is assessing a child suspected of having Kawasaki disease. Which finding is consistent with this diagnosis?

What is kawasaki disease?

Untreated, it can damage the coronary arteries and cause aneurysms, making early recognition and treatment critical. It is diagnosed clinically by a prolonged high fever plus characteristic mucocutaneous findings.

Kawasaki Disease illustrated

Kawasaki Disease — medical illustration
Kawasaki Disease — medical illustration. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • A high fever lasting 5 or more days that is unresponsive to antipyretics is the hallmark.
  • Bilateral nonexudative conjunctivitis (red eyes without drainage) is characteristic.
  • Oral changes include a strawberry tongue and red, cracked, fissured lips.
  • A polymorphous rash appears mainly on the trunk and in the groin.
  • Hands and feet show erythema and edema, followed by peeling (desquamation) of the fingertips and toes during recovery.
  • Cervical lymphadenopathy and extreme irritability are common; coronary artery aneurysm is the most serious complication.

Signs & symptoms

  • Fever > 5 days, unresponsive
  • Strawberry tongue, cracked lips
  • Conjunctivitis, rash, peeling palms
  • Cervical lymphadenopathy, edema

Nursing priorities

  1. Administer high-dose IV immunoglobulin (IVIG) as ordered to reduce the risk of coronary artery aneurysm.
  2. Give aspirin as ordered for its anti-inflammatory and later antiplatelet effects, monitoring for bleeding.
  3. Monitor cardiac status, temperature, intake and output, and fluid balance closely.
  4. Provide comfort measures for irritability, oral care for cracked lips, and skin care for the rash and peeling.
  5. Promote rest, monitor for IVIG reactions, and prepare for echocardiography to evaluate the coronary arteries.

Labs & values

WBC: normal5,000-10,000/mm3, often elevated
Platelets: normal150,000-400,000/mm3, markedly elevated in the subacute phase
ESR and CRP: elevated, reflecting inflammation

Patient teaching

  • Give aspirin exactly as prescribed and report any unusual bruising or bleeding.
  • Skin peeling on the hands and feet is expected during recovery and is not harmful.
  • Avoid live vaccines (such as MMR and varicella) for about 11 months after IVIG, and keep all cardiology follow-up visits.
  • Report return of fever, chest pain, irritability, or signs of a viral illness while on aspirin.

Red flags: report now

  • Signs of coronary involvement (chest pain, dysrhythmias, signs of myocardial infarction) require immediate action.
  • Watch for and report any bleeding while the child is on aspirin therapy.
  • Because of aspirin use, watch for signs of Reye syndrome if the child develops a viral illness such as flu or varicella.
  • Persistent fever after IVIG may indicate the need for retreatment and must be reported.

References

Clinical references for this topic

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