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Physiological Adaptation↓ pH, ↓ HCO₃⁻

Metabolic AcidosisNCLEX cheat sheet

Metabolic acidosis is a low blood pH (below 7.35) caused by either a gain of acid or a loss of bicarbonate, reflected in a low bicarbonate (HCO3 below 22).

25 key facts 5 practice questions Reviewed Oct 2026
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Labs

  • pH < 7.35, HCO₃ < 22
  • Lungs blow off CO₂ (compensate)

Signs

  • Kussmaul breathing (deep/fast)
  • Confusion, drowsy, warm flush
  • ↑ K (hyperkalemia)

Report

  • Dysrhythmias from ↑ K
  • Coma, fatal if untreated

Causes

  • DKA, lactic acidosis, renal fail
  • Diarrhea, shock
Red flag to remember

Dysrhythmias from hyperkalemia - obtain ECG and notify provider immediately.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client in septic shock develops lactic acidosis. Which arterial blood gas value most directly reflects this metabolic problem?

What is metabolic acidosis?

Common causes include diabetic ketoacidosis, lactic acidosis (shock), renal failure, and diarrhea (loss of bicarbonate). The body compensates by increasing the respiratory rate and depth (Kussmaul respirations) to blow off CO2 and raise pH. It matters because severe acidosis depresses the heart and central nervous system.

Metabolic Acidosis illustrated

Metabolic Acidosis — medical illustration
Metabolic Acidosis — medical illustration. Illustration: Mikael Häggström via Wikimedia Commons, Public domain.

Key points to remember

  • ABG pattern: low pH (under 7.35) with low HCO3 (under 22 mEq/L); the bicarbonate change drives the disorder.
  • Respiratory compensation produces deep, rapid Kussmaul respirations to exhale CO2 and a low PaCO2.
  • Neurologic signs include headache, confusion, drowsiness, and progression to lethargy and coma.
  • Acidosis shifts potassium out of cells, so hyperkalemia is often present and causes cardiac dysrhythmias.
  • Cardiovascular effects include hypotension, bradycardia, and decreased cardiac contractility.
  • GI symptoms include nausea, vomiting, and abdominal pain; warm flushed skin may be seen.

Common causes

  • DKA, lactic acidosis, renal fail
  • Diarrhea, shock

Signs & symptoms

  • Kussmaul breathing (deep/fast)
  • Confusion, drowsy, warm flush
  • ↑ K (hyperkalemia)

Nursing priorities

  1. Treat the underlying cause (insulin and fluids for DKA, restore perfusion for lactic acidosis, dialysis for renal failure).
  2. Monitor ABGs, potassium, and cardiac rhythm closely.
  3. Support airway and breathing; do not suppress the compensatory Kussmaul respirations.
  4. Administer IV fluids and prepare to give sodium bicarbonate only for severe acidosis per order.
  5. Monitor potassium during treatment, as correcting acidosis can shift potassium back into cells and cause hypokalemia.

Labs & values

pH normal 7.35-7.45; metabolic acidosis pH less than 7.35
HCO3 normal 22-26 mEq/L; decreased (under 22) in metabolic acidosis
PaCO2 normal 35-45 mmHg; decreased with respiratory compensation

Patient teaching

  • Diabetic clients should monitor glucose and ketones and seek care for persistent high glucose or vomiting.
  • Take chronic kidney disease medications and attend dialysis as prescribed.
  • Report increasing fatigue, confusion, deep rapid breathing, or persistent diarrhea.

Red flags: report now

  • Dysrhythmias from hyperkalemia - obtain ECG and notify provider immediately.
  • Decreasing level of consciousness, profound hypotension, or pH below 7.20 - escalate urgently.
  • During correction, watch for a sudden drop in potassium that can also cause dysrhythmias.

References

Clinical references for this topic

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