Multiple Myeloma — NCLEX Cheat Sheet
Plasma cell cancer → bone + Ca↑
👤 By the CinnaRN Clinical Content Team
🕐 Updated 2026-07-11
🏷️ Physiological Adaptation
🔖 Free to read, print, and share
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Use this quick-reference guide to spot, treat, and prevent Multiple Myeloma on the NCLEX. Keep it handy during review and on exam day!
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- malignant plasma cells in marrow
- destroy bone → ↑calcium
- CRAB: ↑Ca, Renal, Anemia, Bone
- deep bone pain, pathologic fx
- fatigue, frequent infection
- ↑Ca, ↑Bence-Jones protein urine
- ↑creat, ↓Hgb, M-protein spike
- ↑fluids 3 L → flush Ca + protein
- ambulate (↓Ca), fall precautions
- bisphosphonates, pain control
- report ↑Ca: confusion, weakness
✨Quick Tip
Bone destruction causes deep bone pain (especially back and ribs) and pathologic fractures.
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