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Psychosocial IntegrityWithdrawal from maternal opioids

Neonatal Abstinence SyndromeNCLEX cheat sheet

Neonatal abstinence syndrome (NAS) is a constellation of withdrawal signs in a newborn exposed in utero to opioids or other substances.

23 key facts 4 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Mech

  • In-utero drug exposure → withdrawal
  • Opioids most common cause

Signs

  • High-pitched cry, irritable, jittery
  • Tremors, hypertonia, poor feeding
  • Diarrhea, sweating, sneezing, yawning
  • Seizures = severe

Do

  • Swaddle, dim lights, low stimulation
  • Small frequent feeds, ↑ calorie
  • Morphine/methadone taper if severe

Report

  • Seizures, severe dehydration, poor weight
Red flag to remember

Report seizures, apnea, or inability to console/feed.

Before you read

Test yourself first: 4 questions

Question 1 of 4

A client is being discharged with a new antipsychotic. The nurse teaches the family to report which serious effect immediately?

What is neonatal abstinence syndrome?

After birth the maternal drug supply is cut off, producing central nervous system irritability, autonomic instability, and gastrointestinal and respiratory disturbances. Care centers on a quiet, low-stimulation environment, scoring of withdrawal severity, and sometimes pharmacologic weaning.

Key points to remember

  • Classic signs are a high-pitched cry, hyperactive reflexes/tremors, irritability, poor feeding, and a difficult-to-console state.
  • Other findings include excessive sucking, frequent yawning/sneezing, sweating, nasal stuffiness, diarrhea, and poor weight gain.
  • A standardized tool (e.g., Finnegan scoring) guides assessment and pharmacologic treatment decisions.
  • Pharmacologic management may use morphine or methadone with gradual weaning for opioid withdrawal.
  • A swaddled, quiet, dimly lit environment with minimal stimulation reduces irritability.
  • Skin breakdown from frequent loose stools and constant movement is a common complication.

Signs & symptoms

  • High-pitched cry, irritable, jittery
  • Tremors, hypertonia, poor feeding
  • Diarrhea, sweating, sneezing, yawning
  • Seizures = severe

Nursing priorities

  1. Provide a calm, low-stimulation environment: swaddle snugly, dim lights, reduce noise, and cluster care.
  2. Assess withdrawal severity with a scoring tool and administer/wean medications as ordered.
  3. Offer small, frequent feedings and monitor weight, intake, and output.
  4. Protect skin integrity, especially the diaper area and chin/knees from rubbing.
  5. Support maternal-infant bonding and connect the mother to substance-use resources without judgment.

Labs & values

Neonatal/maternal urine or meconium drug screen (positive confirms exposure)
Monitor weight and glucose for adequacy of intake

Patient teaching

  • Teach caregivers gentle soothing: swaddling, vertical rocking, a pacifier, and a quiet dim room.
  • Explain the importance of small frequent feeds and tracking weight.
  • Provide nonjudgmental support and referrals for maternal recovery and follow-up care.

Red flags: report now

  • Report seizures, apnea, or inability to console/feed.
  • Report poor weight gain, dehydration, or severe diarrhea/vomiting.
  • Report rising withdrawal scores indicating need for or escalation of medication.

References

Clinical references for this topic

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