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Physiological AdaptationBili before 24h = pathologic

Neonatal JaundiceNCLEX cheat sheet

Neonatal jaundice is yellowing of the skin and sclera from elevated unconjugated (indirect) bilirubin as fetal red blood cells break down faster than the immature liver can conjugate them.

20 key facts 3 practice questions Reviewed Oct 2026
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Types

  • Physiologic → after 24h, peaks day 3-5
  • Pathologic → <24h, hemolysis/ABO

Labs

  • ↑ unconjugated bilirubin
  • Bili >20 risk → kernicterus

Report

  • Kernicterus → brain damage, lethargy
  • Jaundice in first 24h
  • High-pitched cry, poor feeding

Do

  • Phototherapy → eyes covered, naked
  • ↑ feeds → flush bilirubin in stool
  • Monitor temp, hydration, output
Red flag to remember

Report jaundice appearing within the first 24 hours of life (pathologic).

Before you read

Test yourself first: 3 questions

Question 1 of 3

A nurse is teaching new parents how to assess for jaundice. Which statement reflects an understanding that requires no further intervention regarding the TIMING of jaundice?

What is neonatal jaundice?

Physiologic jaundice appears after 24 hours of life and peaks around days 3-5. Jaundice within the first 24 hours is always pathologic and often due to hemolysis such as Rh/ABO incompatibility.

Key points to remember

  • Jaundice progresses cephalocaudally, beginning at the head/face and moving down the body as bilirubin rises.
  • Jaundice appearing in the first 24 hours of life is pathologic and requires prompt evaluation.
  • Phototherapy converts unconjugated bilirubin into water-soluble forms that are excreted; the eyes are covered and the diaper area kept minimal to maximize skin exposure.
  • Frequent feeding promotes stooling, which eliminates bilirubin and helps prevent dehydration-related rises.
  • Kernicterus (bilirubin encephalopathy) is irreversible brain damage from very high unconjugated bilirubin crossing the blood-brain barrier.
  • Breastfeeding jaundice (early, from underfeeding) differs from breast-milk jaundice (later onset).

Nursing priorities

  1. Monitor transcutaneous/serum bilirubin levels and plot against age in hours on the nomogram.
  2. Promote frequent feeding (8-12 times/day) to enhance bilirubin elimination.
  3. During phototherapy, protect the eyes with shields, expose maximal skin, reposition often, and monitor temperature and hydration.
  4. Assess for signs of bilirubin toxicity and ensure adequate output (wet diapers, stools).
  5. Identify risk factors such as prematurity, bruising/cephalohematoma, and blood-type incompatibility.

Labs & values

Total serum bilirubin: interpreted by age in hours; concern generally rises above ~12-15 mg/dL in term infants
Cord/direct Coombs test positive in immune hemolysis (Rh/ABO)
Hematocrit/reticulocyte count to assess hemolysis
1215mg/dL Normal

Patient teaching

  • Feed the baby frequently to help clear bilirubin through stooling.
  • Watch at home for increasing yellow color spreading to the trunk, arms, or legs and report it.
  • Sunlight through a window is not adequate treatment; follow up for bilirubin checks as scheduled.

Red flags: report now

  • Report jaundice appearing within the first 24 hours of life (pathologic).
  • Report lethargy, poor feeding, high-pitched cry, hypertonia/arching, or seizures (kernicterus).
  • Report rapidly rising bilirubin or levels approaching the exchange-transfusion threshold.

References

Clinical references for this topic

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