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Physiological AdaptationBone infection → fever + bone pain

OsteomyelitisNCLEX cheat sheet

Osteomyelitis is an infection of the bone, most often caused by Staphylococcus aureus, that reaches bone through the bloodstream, open fractures, or surgical wounds.

24 key facts 2 practice questions Reviewed Oct 2026
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Causes

  • S. aureus most common organism
  • Open fx, surgery, blood spread

Signs

  • Bone pain, fever, ↑ WBC/ESR/CRP
  • Redness, warmth, drainage at site

Meds

  • IV abx 4-6 wks (long course)
  • Get cultures BEFORE first abx

Do

  • Immobilize limb, no weight-bearing
  • Sterile dressing changes
  • Watch sepsis: ↑HR, ↓BP, fever
Red flag to remember

Spreading redness, increased drainage, or new fever during treatment signals worsening infection; report it.

Before you read

Test yourself first: 2 questions

Question 1 of 2

A client with suspected osteomyelitis of the tibia is admitted. Which clinical findings does the nurse expect?

What is osteomyelitis?

It can become chronic and difficult to treat because antibiotics penetrate infected bone poorly. Diabetics and those with open fractures or orthopedic hardware are at high risk.

Osteomyelitis illustrated

Osteomyelitis — clinical diagram
Osteomyelitis — clinical diagram. Illustration: Scientific Animations via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Acute signs include bone pain that is constant and worsens with movement, fever, chills, and malaise.
  • The affected area is warm, swollen, tender, and erythematous with possible drainage.
  • Staphylococcus aureus is the most common causative organism.
  • Chronic osteomyelitis features a draining sinus tract and persistent or recurrent infection.
  • Diabetes, peripheral vascular disease, open fractures, and prosthetic implants increase risk.
  • Treatment requires prolonged IV antibiotics, often 4 to 6 weeks or longer.

Common causes

  • S. aureus most common organism
  • Open fx, surgery, blood spread

Signs & symptoms

  • Bone pain, fever, ↑ WBC/ESR/CRP
  • Redness, warmth, drainage at site

Nursing priorities

  1. Administer long-term IV antibiotics on schedule and monitor for therapeutic response.
  2. Immobilize and gently handle the affected limb to reduce pain and prevent fracture.
  3. Maintain strict aseptic technique during dressing changes of any wounds.
  4. Manage pain and elevate the affected extremity to decrease swelling.
  5. Provide adequate nutrition with protein and vitamin C to support tissue healing.

Labs & values

WBC:5,000 to 10,000/mm3 (elevated)
ESR:0 to 20 mm/hr (markedly elevated)
C-reactive protein: less than1.0 mg/dL (elevated)

Patient teaching

  • Complete the entire prolonged course of antibiotics even after symptoms improve.
  • Care for a central line at home safely and report fever, increased pain, or new drainage.
  • Eat a high-protein, high-vitamin-C diet to promote bone and tissue healing.

Red flags: report now

  • Spreading redness, increased drainage, or new fever during treatment signals worsening infection; report it.
  • Signs of sepsis (hypotension, tachycardia, high fever, confusion) require immediate escalation.
  • Never disrupt aseptic technique during wound care, as it can introduce new organisms.

References

Clinical references for this topic

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