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Pyelonephritis — NCLEX Cheat Sheet

Kidney infection + flank pain
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👤 By the CinnaRN Clinical Content Team 🕐 Updated 2026-08-23 🏷️ Physiological Adaptation 🔖 Free to read, print, and share

Also known as: kidney infection · upper UTI · infected kidney · flank infection

Pyelonephritis: infection involving the kidney
Pyelonephritis: infection involving the kidney. Illustration: https://www.myupchar.com/en via Wikimedia Commons, CC BY-SA 4.0.
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Use this quick-reference guide to spot, treat, and prevent Pyelonephritis on the NCLEX. Keep it handy during review and on exam day!

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📒 The 1-minute cheat sheet

📌 Mech

  • UTI ascended to kidney
  • E. coli, reflux, obstruction

🩺 Signs

  • FLANK pain, CVA tenderness
  • HIGH fever, chills, N/V
  • dysuria, frequency, cloudy urine

🚩 Report

  • sepsis: ↑HR, ↓BP, ↑lactate
  • chronic → scarring, CKD

✅ Do

  • IV antibiotics, then oral
  • ↑fluids, antipyretics, rest
  • culture first, monitor I&O

📚 Pyelonephritis — full study notes

The cheat sheet above is your quick recall card. These notes go deeper — what it is, what to do first, what must be reported, and what to teach.

Pyelonephritis is a bacterial infection of one or both kidneys and renal pelvis, usually from an ascending lower urinary tract infection. It is more severe than cystitis and can lead to renal scarring, abscess, or urosepsis. Common causes include untreated UTIs, urinary obstruction, reflux, and pregnancy. Prompt treatment is important to prevent kidney damage and sepsis.
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Key points

Understand these first

Nursing priorities

What to do, in order
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Red flags — report now

Escalate immediately
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Labs & values

Numbers to know
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Patient teaching

What patients must know

❓ Pyelonephritis: NCLEX FAQs

What are the priority nursing interventions for Pyelonephritis?

Obtain urine and blood cultures before initiating antibiotics. Administer IV antibiotics, antipyretics, and IV fluids as ordered. Encourage oral fluid intake (up to 3 L/day) to flush the urinary tract unless contraindicated. Monitor temperature, vital signs, intake/output, and pain.

What are the warning signs of Pyelonephritis a nurse must report?

Hypotension, tachycardia, and high fever - signs of urosepsis/septic shock; escalate immediately. Decreasing urine output or worsening flank pain - possible obstruction or kidney damage; report. Persistent high fever despite antibiotics may indicate abscess - notify provider. Confusion or altered mental status, especially in older adults - report.

What do I need to know about Pyelonephritis for the NCLEX?

Hallmark signs are costovertebral angle (flank) tenderness, high fever, and chills. Patients also have classic UTI symptoms: dysuria, frequency, urgency, and cloudy/foul urine. Nausea, vomiting, and malaise commonly accompany the infection. Urinalysis shows WBC casts, pyuria, bacteria, and possibly hematuria.

What patient teaching is important for Pyelonephritis?

Complete the full course of antibiotics even after symptoms resolve. Drink plenty of fluids and empty the bladder regularly and completely. Treat lower UTIs promptly and report flank pain or fever right away.

Quick Tip

Hallmark signs are costovertebral angle (flank) tenderness, high fever, and chills.

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