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Physiological AdaptationKidney infection + flank pain

PyelonephritisNCLEX cheat sheet

Pyelonephritis is a bacterial infection of one or both kidneys and renal pelvis, usually from an ascending lower urinary tract infection.

24 key facts 1 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Mech

  • UTI ascended to kidney
  • E. coli, reflux, obstruction

Signs

  • FLANK pain, CVA tenderness
  • HIGH fever, chills, N/V
  • dysuria, frequency, cloudy urine

Report

  • sepsis: ↑HR, ↓BP, ↑lactate
  • chronic → scarring, CKD

Do

  • IV antibiotics, then oral
  • ↑fluids, antipyretics, rest
  • culture first, monitor I&O
Red flag to remember

Hypotension, tachycardia, and high fever - signs of urosepsis/septic shock; escalate immediately.

Before you read

Test yourself first: 1 question

Question 1 of 1

A client is admitted with suspected pyelonephritis. Which clinical manifestation does the nurse expect that distinguishes it from a simple lower UTI?

What is pyelonephritis?

It is more severe than cystitis and can lead to renal scarring, abscess, or urosepsis. Common causes include untreated UTIs, urinary obstruction, reflux, and pregnancy. Prompt treatment is important to prevent kidney damage and sepsis.

Pyelonephritis illustrated

Pyelonephritis: infection involving the kidney
Pyelonephritis: infection involving the kidney. Illustration: https://www.myupchar.com/en via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Hallmark signs are costovertebral angle (flank) tenderness, high fever, and chills.
  • Patients also have classic UTI symptoms: dysuria, frequency, urgency, and cloudy/foul urine.
  • Nausea, vomiting, and malaise commonly accompany the infection.
  • Urinalysis shows WBC casts, pyuria, bacteria, and possibly hematuria.
  • Obstruction (stones, BPH) and vesicoureteral reflux predispose to ascending infection.
  • Untreated infection can progress to bacteremia and septic shock.

Signs & symptoms

  • FLANK pain, CVA tenderness
  • HIGH fever, chills, N/V
  • dysuria, frequency, cloudy urine

Nursing priorities

  1. Obtain urine and blood cultures before initiating antibiotics.
  2. Administer IV antibiotics, antipyretics, and IV fluids as ordered.
  3. Encourage oral fluid intake (up to 3 L/day) to flush the urinary tract unless contraindicated.
  4. Monitor temperature, vital signs, intake/output, and pain.
  5. Assess for and relieve any urinary obstruction contributing to the infection.

Labs & values

Urinalysis: WBC casts, pyuria, bacteria, nitrites
Urine and blood cultures: identify organism
WBC: normal5,000-10,000/mm3 (elevated with left shift)

Patient teaching

  • Complete the full course of antibiotics even after symptoms resolve.
  • Drink plenty of fluids and empty the bladder regularly and completely.
  • Treat lower UTIs promptly and report flank pain or fever right away.

Red flags: report now

  • Hypotension, tachycardia, and high fever - signs of urosepsis/septic shock; escalate immediately.
  • Decreasing urine output or worsening flank pain - possible obstruction or kidney damage; report.
  • Persistent high fever despite antibiotics may indicate abscess - notify provider.
  • Confusion or altered mental status, especially in older adults - report.

References

Clinical references for this topic

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