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Physiological AdaptationPost-strep → damages heart valves

Rheumatic FeverNCLEX cheat sheet

Rheumatic fever is an inflammatory autoimmune reaction that follows an untreated group A beta-hemolytic streptococcal infection, usually strep throat.

26 key facts 5 practice questions Reviewed Oct 2026
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Cause

  • Untreated group A strep
  • Autoimmune rxn 2-3 wks later

Signs

  • JONES: Joints, carditis
  • Nodules, erythema, chorea
  • Fever, ↑ASO titer, ↑ESR

Risk

  • Carditis → valve damage
  • Mitral stenosis later

Do

  • Penicillin → treat + prophylaxis
  • Treat strep promptly = prevent
Red flag to remember

New murmur, tachycardia, chest pain, or signs of heart failure indicate carditis — report promptly.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A child presents with a sandpaper-like rash, fever, and a strawberry tongue. The nurse recognizes these findings as characteristic of which infection?

What is rheumatic fever?

It can damage the heart, joints, skin, and nervous system, and is the leading cause of acquired valve disease (especially mitral stenosis). Prompt antibiotic treatment of strep throat prevents it.

Key points to remember

  • Develops 2-3 weeks after an untreated group A streptococcal pharyngitis.
  • Carditis is the most serious manifestation and can permanently scar heart valves.
  • Major Jones criteria include carditis, migratory polyarthritis, chorea, subcutaneous nodules, and erythema marginatum.
  • Diagnosis is supported by elevated ASO titer and evidence of recent strep infection.
  • Long-term prophylactic penicillin prevents recurrence and further valve damage.
  • Treating strep throat with full-course antibiotics prevents rheumatic fever.

Common causes

  • Untreated group A strep
  • Autoimmune rxn 2-3 wks later

Signs & symptoms

  • JONES: Joints, carditis
  • Nodules, erythema, chorea
  • Fever, ↑ASO titer, ↑ESR

Nursing priorities

  1. Administer prescribed antibiotics (penicillin) to eradicate streptococcus and complete the full course.
  2. Provide anti-inflammatory therapy (aspirin/NSAIDs) and monitor for relief of joint inflammation.
  3. Assess cardiac status: heart sounds, murmurs, rhythm, and signs of heart failure.
  4. Promote rest during the acute inflammatory and carditis phase.
  5. Educate on lifelong prophylactic antibiotics to prevent recurrence.

Labs & values

Elevated ASO (antistreptolysin O) titer indicates recent strep infection
Elevated ESR (normal0-20 mm/hr) and CRP (normal under 1 mg/dL) reflect active inflammation
Positive throat culture or rapid strep test for group A strep

Patient teaching

  • Always complete the full course of antibiotics for strep throat to prevent rheumatic fever.
  • Take prophylactic antibiotics long term as prescribed to prevent recurrence.
  • Report sore throats promptly for evaluation and treatment.
  • Inform providers of rheumatic fever history before dental/invasive procedures due to valve risk.

Red flags: report now

  • New murmur, tachycardia, chest pain, or signs of heart failure indicate carditis — report promptly.
  • Sudden involuntary jerky movements (Sydenham chorea) require evaluation.
  • Recurrent sore throats untreated risk repeat episodes and cumulative valve damage.

References

Clinical references for this topic

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