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Physiological AdaptationSymmetric joints + morning stiffness

Rheumatoid ArthritisNCLEX cheat sheet

Rheumatoid arthritis is a chronic, systemic autoimmune disease that causes inflammation of the synovial joints, leading to symmetric joint destruction and deformity.

23 key facts 2 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Signs

  • Symmetric small joints (hands/wrists)
  • Morning stiffness > 1 hr
  • Swelling, warmth, fatigue, fever

Labs

  • +RF, +anti-CCP, ↑ ESR/CRP

Meds

  • DMARDs: methotrexate (1st line)
  • MTX: no alcohol, monitor liver/CBC
  • Biologics → infection risk

Teach

  • Warm/moist heat, balance rest+activity
  • ROM exercises, protect joints
Red flag to remember

Signs of infection in a patient on immunosuppressants (methotrexate, biologics) require prompt reporting.

Before you read

Test yourself first: 2 questions

Question 1 of 2

The nurse is caring for a client with osteoarthritis of the knees. Which characteristic of the joint pain helps distinguish osteoarthritis from rheumatoid arthritis?

What is rheumatoid arthritis?

Unlike osteoarthritis, it affects joints bilaterally and is accompanied by systemic symptoms like fatigue and fever. It tends to flare and remit and is more common in women.

Rheumatoid Arthritis illustrated

Rheumatoid arthritis: an inflamed, swollen joint
Rheumatoid arthritis: an inflamed, swollen joint. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Joint involvement is symmetric and bilateral, classically affecting the small joints of the hands and feet.
  • Morning stiffness lasting longer than one hour is a hallmark and improves with activity.
  • Systemic symptoms include fatigue, low-grade fever, weight loss, and malaise.
  • Chronic inflammation causes deformities such as ulnar drift, swan-neck, and boutonniere of the fingers.
  • Subcutaneous rheumatoid nodules may appear over bony prominences.
  • Positive rheumatoid factor and anti-CCP antibodies support the diagnosis.

Signs & symptoms

  • Symmetric small joints (hands/wrists)
  • Morning stiffness > 1 hr
  • Swelling, warmth, fatigue, fever

Nursing priorities

  1. Apply heat for chronic stiffness and cold to acutely inflamed joints to manage pain.
  2. Encourage a balance of rest during flares and gentle range-of-motion exercise to preserve function.
  3. Administer DMARDs (methotrexate), NSAIDs, and corticosteroids as ordered and monitor for side effects.
  4. Promote use of assistive devices and joint protection techniques.
  5. Schedule activities to allow rest periods and conserve energy.

Labs & values

ESR:0 to 20 mm/hr (elevated during active disease)
C-reactive protein: less than1.0 mg/dL (elevated)
Rheumatoid factor and anti-CCP: positive in RA

Patient teaching

  • Take methotrexate exactly as prescribed, avoid alcohol, use sun protection, and report mouth sores or fever.
  • Apply heat for stiffness and cold for swelling, and perform gentle range-of-motion exercises daily.
  • Balance activity with rest, use larger joints for tasks, and avoid prolonged gripping to protect joints.

Red flags: report now

  • Signs of infection in a patient on immunosuppressants (methotrexate, biologics) require prompt reporting.
  • Methotrexate toxicity (mouth sores, severe fatigue, bleeding, liver changes) must be reported immediately.
  • Sudden severe joint pain, swelling, and warmth may indicate septic arthritis rather than a flare.

References

Clinical references for this topic

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