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Safety & Infection ControlStandard = ALL patients, always

Standard and Transmission-Based PrecautionsNCLEX cheat sheet

Standard precautions are used for EVERY patient regardless of diagnosis and treat all blood and body fluids as potentially infectious.

18 key facts 5 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Standard

  • All patients: gloves, hand hygiene
  • PPE if contact w/ body fluids

Contact

  • Gown + gloves: C.diff, MRSA, VRE

Droplet

  • Mask: flu, pertussis, meningitis
  • Private room, 3-6 ft spacing

Airborne

  • N95 + negative-pressure room
  • My Chicken Hez TB: measles, TB, varicella
Red flag to remember

Never use alcohol-based hand rub alone for C. difficile or other spore-forming organisms; wash with soap and water.

Before you read

Test yourself first: 5 questions

Question 1 of 5

The nurse is caring for a client with Clostridioides difficile (C. diff) infection. Which action is most important to prevent transmission?

What is standard and transmission-based precautions?

Transmission-based precautions are added on top of standard precautions when a specific organism's spread route is known: contact, droplet, or airborne. Correct precautions and PPE protect the patient, staff, and other patients, and are a constant NCLEX safety theme. Remember the airborne mnemonic My Chicken Hez TB: Measles, Chickenpox (varicella), Herpes zoster disseminated, TB.

Key points to remember

  • Standard precautions include hand hygiene, gloves when contacting body fluids, and gown/mask/eye protection when splash is likely, for all patients.
  • Contact precautions (gown and gloves, private room or cohort) apply to C. difficile, MRSA, VRE, RSV, scabies, and draining wounds.
  • Droplet precautions (surgical mask within ~3-6 feet, private room) apply to influenza, pertussis, meningococcal meningitis, mumps, and rubella.
  • Airborne precautions (N95 respirator and negative-pressure room) apply to tuberculosis, measles, and varicella/disseminated zoster.
  • C. difficile and other spore formers require soap-and-water handwashing because alcohol-based gel does not kill spores.
  • PPE is removed in the order gloves, goggles/face shield, gown, then mask/respirator, with hand hygiene after; gown and gloves go on after the respirator when donning.

Nursing priorities

  1. Perform hand hygiene before and after every patient contact and after removing gloves.
  2. Apply the correct precaution type for the organism and post signage so all staff comply.
  3. Place airborne-precaution patients in a negative-pressure room and don an N95 (fit-tested) before entry.
  4. Don and doff PPE in the correct sequence to avoid self-contamination.
  5. Cohort or use a private room when a private room is unavailable, and dedicate equipment to that patient.

Patient teaching

  • Family and visitors must perform hand hygiene and wear the same required PPE before entering the room.
  • Cover coughs, dispose of tissues promptly, and limit movement out of the room while on precautions.
  • Precautions protect you and others and are not a punishment; they end when the infection risk resolves.

Red flags: report now

  • Never use alcohol-based hand rub alone for C. difficile or other spore-forming organisms; wash with soap and water.
  • Never enter an airborne-isolation room without a fit-tested N95 or higher respirator.
  • A breach in PPE or a needlestick exposure must be reported and followed up immediately.
  • Do not transport an isolation patient without proper masking and notifying the receiving area.

References

Clinical references for this topic

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