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Safety & Infection ControlRedness, drainage, fever > 38°C

Surgical Site InfectionNCLEX cheat sheet

A surgical site infection is an infection at or near a surgical incision occurring within 30 days of surgery (or up to 90 days with an implant).

24 key facts 5 practice questions Reviewed Oct 2026
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Signs

  • Redness, warmth, purulent drainage
  • Fever > 38°C, ↑WBC
  • Usually 3–7 days post-op

Prevent

  • Hand hygiene = top measure
  • Sterile dressing, aseptic technique
  • Pre-op abx within 1h incision

Do

  • Culture before starting antibiotics
  • Control glucose < 180 mg/dL

Report

  • Spreading redness, foul drainage
Red flag to remember

Spreading redness, purulent or foul drainage, fever, and increasing pain indicate infection; report and obtain a culture.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A nurse is providing pin site care for a client in skeletal traction. Which observation at a pin site should the nurse report as a sign of infection?

What is surgical site infection?

It causes pain, delayed healing, prolonged hospitalization, and sepsis risk. Common organisms include Staphylococcus aureus (including MRSA). Prevention centers on sterile technique, timely prophylactic antibiotics, glucose control, normothermia, and proper wound care.

Key points to remember

  • Local signs include increasing incisional pain, redness, warmth, swelling, purulent drainage, and wound edge separation.
  • Systemic signs include fever (often appearing after the first 48-72 postoperative hours), chills, and rising WBC count.
  • Major risk factors include diabetes/hyperglycemia, obesity, smoking, immunosuppression, poor nutrition, and prolonged surgery.
  • Prophylactic antibiotics are most effective when given within 60 minutes before incision and stopped within 24 hours.
  • Hyperglycemia, hypothermia, and inadequate tissue oxygenation all impair healing and raise infection risk.
  • Hand hygiene and sterile technique during dressing changes are the most important prevention measures.

Signs & symptoms

  • Redness, warmth, purulent drainage
  • Fever > 38°C, ↑WBC
  • Usually 3–7 days post-op

Nursing priorities

  1. Perform hand hygiene and use strict sterile technique for all dressing changes and wound care.
  2. Assess the incision each shift for redness, warmth, swelling, drainage, odor, and approximation, and monitor temperature and WBC.
  3. Maintain tight glucose control, adequate nutrition (protein, vitamin C, zinc), hydration, and normothermia to support healing.
  4. Administer prophylactic and treatment antibiotics on time; obtain wound cultures before starting antibiotics when infection is suspected.
  5. Educate the patient on incision care and hand hygiene, and ensure proper drain management to prevent fluid collection.

Labs & values

WBC:5,000-10,000/mcL (elevated in infection)
Blood glucose:70-110 mg/dL fasting (hyperglycemia impairs healing)
Albumin:3.5-5.0 g/dL (low reflects poor nutrition and delayed healing)

Patient teaching

  • Wash hands before and after touching the incision and keep the wound clean and dry as instructed.
  • Report increasing redness, swelling, warmth, drainage, foul odor, fever, or increased pain.
  • Eat a protein- and vitamin-C-rich diet, stop smoking, and keep blood sugar controlled to promote healing.

Red flags: report now

  • Spreading redness, purulent or foul drainage, fever, and increasing pain indicate infection; report and obtain a culture.
  • Wound dehiscence (separation) or evisceration (organs protruding) is a surgical emergency; cover with sterile saline-moistened gauze and keep the patient supine with knees bent while notifying the surgeon.
  • High fever, hypotension, tachycardia, and confusion suggest progression to sepsis; escalate immediately.
  • Never apply a soiled or non-sterile dressing or break sterile technique during wound care.

References

Clinical references for this topic

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