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Physiological AdaptationTemp >104°F + tachycardia = emergency

Thyroid Storm (Thyrotoxic Crisis)NCLEX cheat sheet

Thyroid storm is a rare, life-threatening exacerbation of hyperthyroidism with sudden, extreme elevation of thyroid hormone effects.

24 key facts 5 practice questions Reviewed Oct 2026
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Causes

  • Untreated hyperthyroid + stress
  • Infection, surgery, DKA trigger

Signs

  • Hyperthermia >104°F (40°C)
  • HR >130, dysrhythmias, HTN
  • Delirium, agitation, seizures

Do

  • Cooling, O2, IV fluids
  • PTU, then iodine (SSKI) after
  • Propranolol, hydrocortisone

Avoid

  • ASA → ↑ free thyroid hormone
  • Iodine BEFORE PTU given
Key takeaway

Hallmark findings are very high fever (often above 104F/40C), severe tachycardia, and hypertension.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client is admitted in thyroid storm (thyrotoxic crisis). Which set of vital signs is most consistent with this emergency?

What is thyroid storm (thyrotoxic crisis)?

It is often triggered by infection, surgery, trauma, or abrupt withdrawal of antithyroid medication in an undertreated patient. It is a true emergency: untreated mortality is high, and death results from hyperthermia and cardiac collapse.

Key points to remember

  • Hallmark findings are very high fever (often above 104F/40C), severe tachycardia, and hypertension.
  • Central nervous system effects include agitation, delirium, restlessness, seizures, and progression to coma.
  • GI effects include nausea, vomiting, and diarrhea, contributing to dehydration.
  • Dysrhythmias, especially atrial fibrillation, and high-output heart failure can develop.
  • Common precipitants include infection, recent thyroid or other surgery, trauma, and stopping antithyroid drugs.

Common causes

  • Untreated hyperthyroid + stress
  • Infection, surgery, DKA trigger

Signs & symptoms

  • Hyperthermia >104°F (40°C)
  • HR >130, dysrhythmias, HTN
  • Delirium, agitation, seizures

Nursing priorities

  1. Maintain airway and circulation, and aggressively lower temperature with cooling blankets and acetaminophen (never aspirin).
  2. Administer antithyroid drugs (PTU or methimazole), then iodine, plus beta blockers and corticosteroids as ordered.
  3. Provide continuous cardiac monitoring and treat dysrhythmias and heart failure.
  4. Give IV fluids and electrolyte replacement, and provide a cool, calm, quiet environment.
  5. Identify and treat the underlying trigger such as infection.

Labs & values

TSH: very low (normal0.4-4.0 mIU/L)
Free T4 and Free T3: markedly elevated
Glucose: may be elevated
0.44.0mIU/L Normal Thyroid Storm (Thyrotoxic Crisis)

Patient teaching

  • Never abruptly stop antithyroid medication, as this can trigger thyroid storm.
  • Report fever, infection, or extreme palpitations promptly when you have hyperthyroidism.
  • Keep all follow-up appointments to ensure thyroid levels stay controlled.

Red flags: report now

  • Hyperthermia, severe tachycardia, and altered mental status together demand immediate emergency intervention.
  • Never give aspirin, which displaces thyroid hormone from binding proteins and worsens the crisis.
  • Report worsening dysrhythmias, hypotension, or signs of cardiovascular collapse immediately.

References

Clinical references for this topic

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