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Tuberculosis PrecautionsNCLEX cheat sheet

Tuberculosis is caused by Mycobacterium tuberculosis, an airborne organism spread through inhaled droplet nuclei that primarily infects the lungs.

23 key facts 5 practice questions Reviewed Oct 2026
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Precautions

  • Airborne: negative-pressure room
  • N95 respirator (fit-tested)
  • Pt wears surgical mask if transported

Signs

  • Night sweats, hemoptysis, wt loss
  • Chronic cough, low-grade fever

Dx

  • Confirm: 3 sputum AFB cultures
  • +PPD ≥ 10mm; gold standard culture

Meds

  • RIPE x6-9 mo: rifampin, INH, PZA, ethambutol
  • INH → B6 for neuropathy; orange fluids = rifampin
Red flag to remember

Never enter the room of an active TB patient without a fit-tested N95 respirator.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client with active tuberculosis is being discharged home. The nurse teaches the family that:

What is tuberculosis precautions?

Active pulmonary TB requires airborne precautions because the bacteria stay suspended in air. Latent TB is non-infectious and asymptomatic but can reactivate. Treatment is long-term multidrug therapy, and strict adherence is essential to cure and to prevent drug resistance.

Key points to remember

  • Classic symptoms are a chronic productive cough lasting over three weeks, hemoptysis, night sweats, low-grade fever, fatigue, and weight loss.
  • TB spreads by airborne droplet nuclei, so active cases need a negative-pressure room and N95 respirators for staff.
  • A positive PPD/Mantoux or IGRA shows exposure; a chest x-ray and sputum AFB cultures confirm active disease.
  • Standard therapy is months of combined drugs, classically Rifampin, Isoniazid, Pyrazinamide, and Ethambutol (RIPE).
  • The patient is considered noninfectious after adequate treatment yields three consecutive negative sputum AFB smears.
  • Rifampin turns body fluids (urine, sweat, tears) orange-red, and isoniazid can cause peripheral neuropathy and hepatotoxicity.

Signs & symptoms

  • Night sweats, hemoptysis, wt loss
  • Chronic cough, low-grade fever

Nursing priorities

  1. Place the patient in a negative-pressure (airborne isolation) room and keep the door closed.
  2. Wear a fit-tested N95 respirator before entering; have the patient wear a surgical mask when transported.
  3. Administer multidrug therapy on schedule and use directly observed therapy (DOT) to ensure adherence.
  4. Collect sputum specimens for AFB smear and culture as ordered to track infectiousness.
  5. Monitor liver function and give vitamin B6 (pyridoxine) with isoniazid to prevent neuropathy.

Labs & values

PPD/Mantoux positive at varying induration thresholds (5/10/15 mm depending on risk)
Sputum acid-fast bacilli (AFB) smear/culture confirms active TB
AST/ALT monitored for hepatotoxicity (normal AST ~10-40, ALT ~7-56 units/L)

Patient teaching

  • Take all TB medications exactly as prescribed for the full course (months) even after feeling well, to cure infection and prevent resistance.
  • Cover the mouth when coughing, wear a mask in public until cleared, and ensure household contacts get tested.
  • Expect rifampin to turn urine and tears orange, avoid alcohol due to liver risk, and keep all sputum and clinic follow-ups.

Red flags: report now

  • Never enter the room of an active TB patient without a fit-tested N95 respirator.
  • Jaundice, dark urine, right-upper-quadrant pain, or rising liver enzymes signal drug hepatotoxicity and must be reported.
  • Hemoptysis with respiratory distress requires urgent evaluation.
  • Nonadherence to therapy must be addressed immediately because it breeds multidrug-resistant TB.

References

Clinical references for this topic

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