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Physiological AdaptationColon only, bloody diarrhea

Ulcerative ColitisNCLEX cheat sheet

Ulcerative colitis is a chronic inflammatory bowel disease limited to the colon and rectum.

23 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Mech

  • colon + rectum ONLY, continuous
  • mucosa/submucosa only (not deep)
  • starts rectum, moves up

Signs

  • LLQ pain, BLOODY diarrhea
  • 10-20 stools/day, tenesmus
  • wt loss, anemia, dehydration

Report

  • toxic megacolon = emergency
  • distended abd, fever, ↓BP
  • ↑colon cancer risk

Do

  • aminosalicylates, steroids, biologics
  • colectomy = CURE
  • low-residue diet during flare
Key takeaway

Inflammation is continuous and confined to the mucosa/submucosa of the colon and rectum.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A client with ulcerative colitis is experiencing an exacerbation. Which finding is most characteristic of this condition?

What is ulcerative colitis?

Inflammation is continuous (no skip lesions) and affects only the mucosa and submucosa, starting in the rectum and spreading proximally. The hallmark symptom is frequent bloody, mucus-filled diarrhea. Severe disease risks toxic megacolon and increases long-term colon cancer risk.

Ulcerative Colitis illustrated

Ulcerative colitis (continuous, from the rectum, lining only) vs Crohn disease (skip lesions, all layers)
Ulcerative colitis (continuous, from the rectum, lining only) vs Crohn disease (skip lesions, all layers). Illustration: CinnaRN.

Key points to remember

  • Inflammation is continuous and confined to the mucosa/submucosa of the colon and rectum.
  • Frequent bloody diarrhea with mucus, up to 10-20 stools per day, is the hallmark.
  • Left lower quadrant cramping and urgency (tenesmus) are common.
  • Weight loss, fever, anemia, and dehydration occur with active disease.
  • Toxic megacolon is a life-threatening complication of severe inflammation.
  • Long-standing ulcerative colitis significantly increases colorectal cancer risk.

Signs & symptoms

  • LLQ pain, BLOODY diarrhea
  • 10-20 stools/day, tenesmus
  • wt loss, anemia, dehydration

Nursing priorities

  1. Monitor frequency and character of stools and assess for bleeding and dehydration.
  2. Administer aminosalicylates, corticosteroids, and immunomodulators as prescribed.
  3. Maintain fluid and electrolyte balance; replace losses from diarrhea.
  4. Provide bowel rest with NPO or low-residue diet during severe flares as ordered.
  5. Prepare patient for possible total colectomy in refractory disease, which is curative.

Labs & values

Hemoglobin:12-18 g/dL (decreased with blood loss)
Albumin:3.5-5 g/dL (decreased)
Potassium:3.5-5.0 mEq/L (decreased from diarrhea); ESR/CRP elevated
1218g/dL Normal

Patient teaching

  • Maintain hydration and follow a low-residue diet during flares.
  • Undergo regular colonoscopy screening due to elevated colon cancer risk.
  • Report increasing diarrhea, blood loss, fever, or abdominal distention.

Red flags: report now

  • Abdominal distention, fever, and tachycardia suggest toxic megacolon, a surgical emergency.
  • Profuse bloody diarrhea with signs of hypovolemia requires immediate intervention.
  • Sudden severe abdominal pain with rigidity may indicate perforation.

References

Clinical references for this topic

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