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Physiological AdaptationH. pylori + NSAIDs = ulcer

Peptic Ulcer DiseaseNCLEX cheat sheet

Peptic ulcer disease is an erosion in the lining of the stomach (gastric) or duodenum caused by an imbalance between digestive acid and the mucosal barrier.

25 key facts 5 practice questions Reviewed Oct 2026
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Causes

  • H. pylori, NSAIDs, ↑ stomach acid
  • smoking, ETOH, stress, steroids

Signs

  • gastric: pain WITH food
  • duodenal: pain 2-3h AFTER, relief w/ food
  • epigastric burning, dyspepsia

Report

  • coffee-ground emesis, melena → bleed
  • rigid board-like abd → perforation
  • sudden severe pain, ↓BP, ↑HR

Meds

  • triple Tx: PPI + 2 antibiotics
  • PPIs (-prazole), H2 (-tidine)
  • sucralfate on empty stomach

Avoid

  • NSAIDs, aspirin, caffeine, ETOH
  • no smoking → delays healing
Key takeaway

Gastric ulcer pain increases with food intake; duodenal ulcer pain is relieved by food and recurs 2-3 hours after meals.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A client with peptic ulcer disease suddenly develops a rigid, board-like abdomen and severe pain. The nurse suspects which complication?

What is peptic ulcer disease?

The two main causes are Helicobacter pylori infection and chronic NSAID/aspirin use. Gastric ulcer pain typically worsens with eating, while duodenal ulcer pain is relieved by eating and returns 2-3 hours later. Major complications are hemorrhage and perforation.

Peptic Ulcer Disease illustrated

Gastric ulcer eroding the stomach lining
Gastric ulcer eroding the stomach lining. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Gastric ulcer pain increases with food intake; duodenal ulcer pain is relieved by food and recurs 2-3 hours after meals.
  • Helicobacter pylori infection and NSAID/aspirin use are the leading causes.
  • Burning or gnawing epigastric pain is the classic symptom.
  • Bleeding ulcers cause hematemesis (coffee-ground or bright red) and melena.
  • Perforation causes sudden, severe, board-like rigid abdomen with rebound tenderness.
  • Duodenal ulcers are more associated with nighttime pain and weight stability; gastric ulcers with weight loss.

Common causes

  • H. pylori, NSAIDs, ↑ stomach acid
  • smoking, ETOH, stress, steroids

Signs & symptoms

  • gastric: pain WITH food
  • duodenal: pain 2-3h AFTER, relief w/ food
  • epigastric burning, dyspepsia

Nursing priorities

  1. Administer proton pump inhibitors or H2 blockers to reduce acid and promote healing.
  2. Give antibiotic combination therapy for H. pylori eradication as prescribed.
  3. Monitor stools and emesis for occult or frank blood and watch for signs of bleeding.
  4. Teach avoidance of NSAIDs, aspirin, alcohol, caffeine, and smoking.
  5. Assess pain pattern in relation to meals to distinguish gastric from duodenal ulcers.

Labs & values

Hemoglobin:12-18 g/dL (decreased with bleeding)
Hematocrit:37-52% (decreased with bleeding)
H. pylori test (urea breath/stool antigen) positive
1218g/dL Normal

Patient teaching

  • Avoid NSAIDs, aspirin, alcohol, caffeine, and smoking, which damage the mucosa.
  • Complete the entire H. pylori antibiotic regimen even if symptoms improve.
  • Report black tarry stools, vomiting blood, or sudden severe abdominal pain immediately.

Red flags: report now

  • Sudden severe abdominal pain with a rigid board-like abdomen indicates perforation, a surgical emergency.
  • Hematemesis or melena with vital sign changes signals active GI hemorrhage.
  • Signs of shock (tachycardia, hypotension, cool clammy skin) require immediate intervention.

References

Clinical references for this topic

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