Peptic Ulcer Disease — NCLEX Cheat Sheet
H. pylori + NSAIDs = ulcer
👤 By the CinnaRN Clinical Content Team
🕐 Updated 2026-07-11
🏷️ Physiological Adaptation
🔖 Free to read, print, and share
Gastric ulcer eroding the stomach lining. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.
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Use this quick-reference guide to spot, treat, and prevent Peptic Ulcer Disease on the NCLEX. Keep it handy during review and on exam day!
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- H. pylori, NSAIDs, ↑ stomach acid
- smoking, ETOH, stress, steroids
- gastric: pain WITH food
- duodenal: pain 2-3h AFTER, relief w/ food
- epigastric burning, dyspepsia
- coffee-ground emesis, melena → bleed
- rigid board-like abd → perforation
- sudden severe pain, ↓BP, ↑HR
- triple Tx: PPI + 2 antibiotics
- PPIs (-prazole), H2 (-tidine)
- sucralfate on empty stomach
- NSAIDs, aspirin, caffeine, ETOH
- no smoking → delays healing
✨Quick Tip
Gastric ulcer pain increases with food intake; duodenal ulcer pain is relieved by food and recurs 2-3 hours after meals.
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