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Physiological AdaptationNew painless breast lump

Breast CancerNCLEX cheat sheet

Breast cancer is a malignant tumor of breast tissue and is the most common cancer in women.

26 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Signs

  • Hard fixed painless lump, upper-outer
  • Skin dimpling, peau d'orange, nipple retraction
  • Bloody/clear unilateral nipple discharge

Risk

  • BRCA1/2, family hx, female, age ↑
  • Early menarche, late menopause, nulliparity

Dx

  • Mammogram, US, biopsy = definitive
  • Receptors: ER/PR/HER2 → guide tx

Do

  • Post-mastectomy: arm elevated, no BP/IV
  • Watch lymphedema → no constriction
  • Tamoxifen → ↑ clot/DVT risk
Red flag to remember

Signs of lymphedema or infection in the affected arm (swelling, redness, warmth) require prompt reporting.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A breastfeeding client returns on postpartum day 10 with a red, warm, tender wedge-shaped area on one breast, fever, and flu-like body aches. What does the nurse suspect?

What is breast cancer?

The classic presentation is a painless, hard, fixed, irregular lump, most often in the upper outer quadrant. Risk rises with age, family history, BRCA1/BRCA2 mutations, prolonged estrogen exposure, and obesity. Early detection through screening and self-awareness improves survival.

Breast Cancer illustrated

Breast cancer within the breast tissue
Breast cancer within the breast tissue. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • The classic sign is a single, hard, painless, fixed, irregular lump, frequently in the upper outer quadrant.
  • Other signs include nipple retraction, skin dimpling, peau d'orange (orange-peel skin), and bloody or clear nipple discharge.
  • Risk factors include female sex, increasing age, BRCA1/BRCA2 mutations, family history, early menarche/late menopause, nulliparity, and prolonged estrogen exposure.
  • Hormone receptor (ER/PR) and HER2 status guide therapy; ER-positive tumors respond to tamoxifen or aromatase inhibitors.
  • Treatment may include lumpectomy or mastectomy, sentinel lymph node biopsy, radiation, chemotherapy, and targeted/hormonal therapy.
  • After axillary lymph node dissection, the affected arm is at risk for lymphedema.

Signs & symptoms

  • Hard fixed painless lump, upper-outer
  • Skin dimpling, peau d'orange, nipple retraction
  • Bloody/clear unilateral nipple discharge

Nursing priorities

  1. After mastectomy, position the affected arm elevated on a pillow to promote lymph drainage.
  2. Protect the affected arm: no BP measurements, venipunctures, or injections on that side.
  3. Encourage progressive arm exercises as ordered to restore range of motion and prevent contractures.
  4. Provide emotional support and address body image and sexuality concerns.
  5. Monitor the surgical site and drains for bleeding, infection, and excessive output.

Labs & values

Tumor markers CA15-3 / CA 27-29: may be elevated (used for monitoring, not screening)
ER/PR receptor status: positive or negative
HER2 status: positive or negative
BRCA1/BRCA2 genetic testing: as indicated

Patient teaching

  • Protect the affected arm: avoid blood draws, BP, injections, heavy lifting, tight clothing/jewelry, and cuts on that side.
  • Perform prescribed arm exercises and report any swelling, redness, or signs of lymphedema or infection.
  • Follow recommended screening: mammography and clinical exams per guidelines; report any new lump or change.
  • Practice monthly breast self-awareness and know normal versus abnormal findings.
  • For hormonal therapy like tamoxifen, report leg pain/swelling or abnormal vaginal bleeding (clot and endometrial cancer risk).

Red flags: report now

  • Signs of lymphedema or infection in the affected arm (swelling, redness, warmth) require prompt reporting.
  • Never take blood pressure, draw blood, or give injections in the arm on the operative/lymph node dissection side.
  • Sudden severe arm swelling, chest pain, or shortness of breath needs immediate evaluation.

References

Clinical references for this topic

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