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Physiological AdaptationRUQ pain + Murphy's sign

CholecystitisNCLEX cheat sheet

Cholecystitis is inflammation of the gallbladder, most often caused by a gallstone (cholelithiasis) obstructing the cystic duct and blocking bile flow.

25 key facts 3 practice questions Reviewed Oct 2026
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Causes

  • Gallstones block cystic duct
  • Fat, female, forty, fertile

Signs

  • RUQ pain → right shoulder
  • Murphy's sign +, worse w/ fatty
  • N/V, fever, clay stool, jaundice

Do

  • NPO, IV fluids, pain meds
  • Lap cholecystectomy = definitive
  • Low-fat diet, small meals

Report

  • T-tube >500 mL/day or no drainage
  • Fever, ↑ pain = perforation
Key takeaway

Right upper quadrant pain that may radiate to the right shoulder or scapula, often after a high-fat meal.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A client with cholecystitis is most likely to report pain that:

What is cholecystitis?

Risk factors are summarized by the 4 F's: Female, Forty, Fat, and Fertile. Pain typically follows a fatty meal because fat triggers gallbladder contraction. Bile obstruction can back up and cause jaundice and clay-colored stools.

Cholecystitis illustrated

Gallstones in the gallbladder and bile duct
Gallstones in the gallbladder and bile duct. Illustration: BruceBlaus via Wikimedia Commons, CC BY-SA 4.0.

Key points to remember

  • Right upper quadrant pain that may radiate to the right shoulder or scapula, often after a high-fat meal.
  • Murphy sign is positive: pain and inspiratory arrest when the RUQ is palpated during deep breath.
  • Nausea, vomiting, fever, and indigestion (dyspepsia) are common.
  • Obstruction of bile flow causes jaundice, dark amber urine, clay-colored stools, and pruritus.
  • Bile is needed to absorb fat-soluble vitamins, so deficiency of A, D, E, and K may occur.
  • The classic risk profile is the 4 F's: female, forty, fat (obese), and fertile.

Common causes

  • Gallstones block cystic duct
  • Fat, female, forty, fertile

Signs & symptoms

  • RUQ pain → right shoulder
  • Murphy's sign +, worse w/ fatty
  • N/V, fever, clay stool, jaundice

Nursing priorities

  1. Keep the patient NPO during acute attacks to rest the gallbladder.
  2. Administer prescribed analgesics and antiemetics; provide IV fluids as ordered.
  3. Prepare and educate the patient for cholecystectomy, often laparoscopic.
  4. Monitor for signs of bile duct obstruction such as worsening jaundice and pale stools.
  5. Administer fat-soluble vitamin supplements and vitamin K if bile flow is impaired, as ordered.

Labs & values

WBC:5,000-10,000/mm3 (elevated with inflammation/infection)
Total bilirubin:0.3-1.0 mg/dL (elevated with obstruction)
Alkaline phosphatase and AST/ALT may be elevated

Patient teaching

  • Eat a low-fat diet and avoid greasy, fried foods that trigger attacks.
  • After cholecystectomy, gradually reintroduce fats and report fever, increasing pain, or jaundice.
  • Report persistent RUQ pain, fever, or yellowing of the skin and eyes.

Red flags: report now

  • Fever, severe RUQ pain, and jaundice may indicate ascending cholangitis or sepsis requiring urgent care.
  • Signs of gallbladder rupture or peritonitis (rigid abdomen, rebound tenderness) need immediate escalation.
  • Clay-colored stools with dark urine and worsening jaundice signal complete bile obstruction.

References

Clinical references for this topic

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