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Physiological AdaptationPain out of proportion = emergency

Compartment SyndromeNCLEX cheat sheet

Compartment syndrome is increased pressure within a closed muscle compartment that cuts off blood flow, leading to ischemia and tissue death.

23 key facts 3 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Mech

  • ↑pressure in compartment
  • blocks blood flow → tissue death
  • from cast, crush, swelling

Signs

  • PAIN out of proportion, ↑w/ stretch
  • unrelieved by opioids = KEY
  • paresthesia, pallor, pulselessness

Do Now

  • notify provider IMMEDIATELY
  • loosen/bivalve cast, remove dressing
  • keep limb at HEART level (not elevate)

Avoid

  • do NOT elevate above heart
  • do NOT apply ice/cold
  • fasciotomy if severe
Key takeaway

The hallmark sign is severe, deep, throbbing pain out of proportion to the injury and unrelieved by opioids.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A client has circumferential full-thickness burns to the entire right arm. The nurse notes the fingers are cool, pale, and the radial pulse is now difficult to palpate. Which complication does the nurse suspect, and what intervention is anticipated?

What is compartment syndrome?

It is a surgical emergency most often seen after fractures, crush injuries, tight casts, or burns. Permanent muscle and nerve damage (and possible amputation) can occur within 4 to 6 hours, so early recognition is critical.

Compartment Syndrome illustrated

Compartment syndrome: swollen muscle inside unstretchable fascia squeezes the vein, artery and nerve
Compartment syndrome: swollen muscle inside unstretchable fascia squeezes the vein, artery and nerve. Illustration: CinnaRN.

Key points to remember

  • The hallmark sign is severe, deep, throbbing pain out of proportion to the injury and unrelieved by opioids.
  • Pain on passive stretch of the muscles is one of the earliest and most reliable findings.
  • The 6 P's are pain, paresthesia, pallor, pulselessness, paralysis, and poikilothermia (coolness).
  • Pulselessness and paralysis are LATE signs; waiting for them risks permanent damage.
  • Compartment pressure above 30 mmHg or within 30 mmHg of diastolic pressure indicates the syndrome.
  • Muscle breakdown releases myoglobin, which can cause acute kidney injury (rhabdomyolysis).

Signs & symptoms

  • PAIN out of proportion, ↑w/ stretch
  • unrelieved by opioids = KEY
  • paresthesia, pallor, pulselessness

Nursing priorities

  1. Notify the provider immediately at the first sign of escalating, unrelievable pain.
  2. Loosen or bivalve a constricting cast or remove restrictive dressings as ordered.
  3. Keep the extremity at heart level, NOT elevated, to maintain arterial perfusion.
  4. Stop applying ice, which causes vasoconstriction and worsens ischemia.
  5. Prepare the patient for an emergency fasciotomy to relieve pressure.

Labs & values

Creatine kinase (CK):30 to 170 U/L (markedly elevated with muscle breakdown)
Serum potassium:3.5 to 5.0 mEq/L (rises with rhabdomyolysis)
Creatinine:0.6 to 1.2 mg/dL (rises with myoglobin-induced kidney injury)

Patient teaching

  • Report any increasing pain, numbness, tingling, or a sensation of tightness immediately.
  • Understand that a fasciotomy wound may be left open temporarily to relieve pressure.

Red flags: report now

  • Pain unrelieved by opioids plus pain on passive stretch is compartment syndrome until proven otherwise.
  • Never elevate the limb above the heart or apply ice; both reduce blood flow and worsen ischemia.
  • Dark, tea-colored urine signals rhabdomyolysis and impending kidney failure; report at once.
  • Loss of pulse or movement means tissue death is imminent and surgery cannot wait.

References

Clinical references for this topic

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