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Physiological AdaptationClot in deep vein

Deep Vein ThrombosisNCLEX cheat sheet

Deep vein thrombosis is a blood clot that forms in a deep vein, most often in the legs, due to the factors of Virchow's triad: blood stasis, vessel wall injury, and hypercoagulability.

21 key facts 3 practice questions Reviewed Oct 2026
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Signs

  • Unilateral leg swelling, warmth
  • Redness, calf pain, tenderness

Report

  • PE: sudden SOB, chest pain
  • Do NOT massage leg

Do

  • Anticoag: heparin → warfarin/DOAC
  • Elevate leg, bed rest early
  • Warm compress, SCDs prevention

Teach

  • Ambulate, hydrate, no crossing legs
  • Bleeding precautions on AC
Key takeaway

The affected limb is typically swollen, warm, red, and tender, often calf or thigh.

Before you read

Test yourself first: 3 questions

Question 1 of 3

A nurse notes an area of intact skin over the heel that is a persistent, nonblanchable deep red, maroon, or purple discoloration. The client reports the area is painful and boggy. How does the nurse classify this finding?

What is deep vein thrombosis?

The most dangerous complication is pulmonary embolism, which occurs if the clot dislodges and travels to the lungs. Risk factors include immobility, surgery, pregnancy, oral contraceptives, and cancer.

Deep Vein Thrombosis illustrated

Deep vein thrombosis: a clot within a deep leg vein
Deep vein thrombosis: a clot within a deep leg vein. Illustration: BruceBlaus via Wikimedia Commons, CC BY 3.0.

Key points to remember

  • The affected limb is typically swollen, warm, red, and tender, often calf or thigh.
  • Unilateral leg swelling with calf pain is a classic finding.
  • Virchow's triad of venous stasis, endothelial injury, and hypercoagulability explains clot formation.
  • Pulmonary embolism is the major life-threatening complication if the clot embolizes.
  • Risk increases with immobility, recent surgery, long travel, pregnancy, estrogen use, and malignancy.

Signs & symptoms

  • Unilateral leg swelling, warmth
  • Redness, calf pain, tenderness

Nursing priorities

  1. Maintain bed rest as ordered initially and elevate the affected extremity to reduce swelling.
  2. Administer anticoagulant therapy such as heparin or low-molecular-weight heparin as prescribed.
  3. Apply warm compresses if ordered and avoid massaging or rubbing the affected leg.
  4. Apply sequential compression devices to unaffected limbs and encourage early ambulation for prevention.
  5. Monitor for signs of pulmonary embolism and for bleeding from anticoagulation.

Labs & values

D-dimer: elevated suggests clot (normal less than0.5 mcg/mL)
aPTT: therapeutic1.5-2.5 times control for heparin (about 46-70 seconds)
INR:2.0-3.0 therapeutic for warfarin; platelets to monitor for HIT

Patient teaching

  • Take anticoagulants exactly as prescribed and watch for and report any signs of bleeding.
  • Avoid prolonged sitting or standing, ambulate frequently, and stay hydrated, especially during long travel.
  • Do not cross the legs or wear constrictive clothing, and report new leg swelling, sudden chest pain, or shortness of breath.

Red flags: report now

  • Sudden dyspnea, sharp pleuritic chest pain, tachycardia, or hypoxia signals pulmonary embolism and is a medical emergency.
  • Never massage or rub the affected limb because it can dislodge the clot.
  • Signs of anticoagulation bleeding such as hematuria, black stools, or unusual bruising must be reported immediately.

References

Clinical references for this topic

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