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Physiological AdaptationClotting THEN bleeding everywhere

Disseminated Intravascular Coagulation (DIC)NCLEX cheat sheet

DIC is a life-threatening disorder in which widespread clotting consumes clotting factors and platelets, paradoxically leaving the patient unable to clot and at risk of massive bleeding.

21 key facts 5 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Mech

  • widespread clotting uses up factors
  • then NO clotting → massive bleed
  • triggers: sepsis, OB, trauma, cancer

Signs

  • bleeding from EVERY site
  • oozing IV/incision, petechiae
  • cyanotic digits (microclots)

Labs

  • ↑D-dimer, ↑PT/PTT, ↓platelets
  • ↓fibrinogen, ↑FDP

Do

  • TREAT underlying cause first
  • FFP, platelets, cryoprecipitate
  • O2, monitor bleeding/clots
Red flag to remember

Report uncontrolled or worsening bleeding from multiple sites and signs of hypovolemic shock.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A nurse reviews labs for a client suspected of having disseminated intravascular coagulation (DIC). Which set of findings is most consistent with DIC?

What is disseminated intravascular coagulation (dic)?

It is always secondary to another trigger such as sepsis, obstetric complications, massive trauma, or cancer. It matters because the patient simultaneously clots (organ ischemia) and bleeds (hemorrhage), and mortality is high.

Disseminated Intravascular Coagulation (DIC) illustrated

DIC: tiny clots block small vessels while used-up platelets and factors let blood leak into tissue
DIC: tiny clots block small vessels while used-up platelets and factors let blood leak into tissue. Illustration: CinnaRN.

Key points to remember

  • Diffuse microclotting consumes platelets and clotting factors, then causes uncontrolled bleeding.
  • DIC is always secondary; common triggers are sepsis, obstetric emergencies, trauma, and malignancy.
  • Bleeding appears from multiple sites at once: IV sites, gums, incisions, and mucous membranes.
  • Microclots cause organ ischemia, seen as cool, mottled, or cyanotic extremities and decreased urine output.
  • D-dimer and fibrin degradation products are elevated while fibrinogen and platelets fall.
  • Both PT and aPTT are prolonged.

Signs & symptoms

  • bleeding from EVERY site
  • oozing IV/incision, petechiae
  • cyanotic digits (microclots)

Nursing priorities

  1. Identify and treat the underlying cause (e.g., antibiotics for sepsis, delivery for obstetric triggers).
  2. Monitor for bleeding from all sites and assess perfusion to extremities and organs.
  3. Administer prescribed blood products: platelets, fresh frozen plasma, and cryoprecipitate.
  4. Protect the patient from injury and avoid invasive procedures and IM injections.
  5. Monitor vital signs, urine output, and neurologic status for shock and organ failure.

Labs & values

Platelets (normal150,000-400,000/mm3) decreased
Fibrinogen (normal200-400 mg/dL) decreased
D-dimer and fibrin degradation products elevated
PT and aPTT prolonged

Red flags: report now

  • Report uncontrolled or worsening bleeding from multiple sites and signs of hypovolemic shock.
  • Report signs of organ ischemia: decreasing urine output, change in level of consciousness, or cyanotic/mottled limbs.
  • Report a falling fibrinogen and platelet count with rising D-dimer, indicating worsening DIC.

References

Clinical references for this topic

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