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Physiological AdaptationSurfactant deficiency in preterm

Respiratory Distress Syndrome (newborn)NCLEX cheat sheet

Respiratory distress syndrome (RDS) of the newborn results from surfactant deficiency in immature lungs, causing alveolar collapse, poor gas exchange, and increased work of breathing.

23 key facts 5 practice questions Reviewed Oct 2026
The 1-minute sheetCinnaRN

Mech

  • ↓ surfactant → alveoli collapse
  • Preterm <34wk = highest risk

Signs

  • Tachypnea, grunting, nasal flaring
  • Retractions, cyanosis, ↓ O2 sat
  • Apnea → respiratory failure

Do

  • Antenatal steroids (betamethasone) → lungs
  • Surfactant via ETT, CPAP/vent
  • Maintain warmth, O2, nutrition

Report

  • Worsening cyanosis, apnea spells
Red flag to remember

Report worsening grunting, retractions, apnea, or cyanosis indicating respiratory failure.

Before you read

Test yourself first: 5 questions

Question 1 of 5

A nurse cares for a newborn of a diabetic mother. Beyond hypoglycemia, which additional complication is this infant at increased risk for and should be monitored for?

What is respiratory distress syndrome (newborn)?

It primarily affects preterm infants and worsens over the first hours of life. Antenatal corticosteroids given to the mother and postnatal surfactant replacement are the cornerstones of prevention and treatment.

Respiratory Distress Syndrome (newborn) illustrated

Newborn respiratory distress: alveoli stay open with surfactant and collapse without it
Newborn respiratory distress: alveoli stay open with surfactant and collapse without it. Illustration: CinnaRN.

Key points to remember

  • Surfactant lowers alveolar surface tension; without it alveoli collapse on expiration (atelectasis).
  • Signs include tachypnea, nasal flaring, grunting, intercostal/substernal retractions, and cyanosis worsening over time.
  • Prematurity is the chief risk factor; surfactant production reaches maturity near 34-36 weeks.
  • Antenatal betamethasone or dexamethasone given to the mother accelerates fetal lung maturity.
  • Exogenous surfactant is administered via the endotracheal tube to replace the missing surfactant.
  • An L/S ratio of at least 2:1 and presence of phosphatidylglycerol indicate fetal lung maturity.

Signs & symptoms

  • Tachypnea, grunting, nasal flaring
  • Retractions, cyanosis, ↓ O2 sat
  • Apnea → respiratory failure

Nursing priorities

  1. Maintain a patent airway and support oxygenation with prescribed oxygen/CPAP or mechanical ventilation.
  2. Administer surfactant via ETT as ordered and monitor respiratory response.
  3. Cluster care and maintain a neutral thermal environment to reduce oxygen consumption.
  4. Continuously monitor oxygen saturation, respiratory effort, and blood gases.
  5. Support the family and explain interventions to reduce anxiety.

Labs & values

ABG showing hypoxemia and respiratory acidosis (low PaO2, high PaCO2, low pH)
Amniotic fluid L/S ratio >=2:1 indicates lung maturity
SpO2 target typically 90-95% per protocol

Patient teaching

  • Explain to parents that antenatal steroids help the baby's lungs mature before birth.
  • Describe that surfactant replacement helps the lungs stay open and improves breathing.
  • Reassure parents about the purpose of CPAP/ventilator support and monitoring.

Red flags: report now

  • Report worsening grunting, retractions, apnea, or cyanosis indicating respiratory failure.
  • Report falling oxygen saturation or rising CO2 despite oxygen support.
  • Avoid excessive oxygen administration that can contribute to retinopathy of prematurity; titrate to ordered targets.

References

Clinical references for this topic

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